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Millstine, Denise M

Mayo Clinic

1 Division of Women's Health-Internal Medicine, Mayo Clinic Arizona , Scottsdale, Arizona.

Citations 8

The Growing Promise of Elinzanetant for Treatment of Menopausal Symptoms—Sustained Relief Without Hormones
Mehta, Jaya , Millstine, Denise , Millstine, Denise M, Manson, JoAnn E.

JAMA Internal Medicine | September 8, 2025 | Volume: 185 | Issue: 11 | Pages: 1328

10.1001/jamainternmed.2025.4436 Get It

Acupuncture as a Complementary Treatment Modality in the Post-Anesthesia Care Setting: A Feasibility Study
Harbell, Monica W. , Barendrick, Lindsay N., Pelkey, Melissa N. , Elam, Debbie E., Bombaci, Nikki A., Mora, Kerri S., Mi, Lanyu , Quillen, Jaxon , Millstine, Denise , Millstine, Denise M, Harbell, Monica W , Pelkey, Melissa N , Barendrick, Lindsay N.

Journal of Integrative and Complementary Medicine | January 12, 2024 | Volume: 30 | Issue: 8 | Pages: 776-782

10.1089/jicm.2023.0168 Get It

Introduction: Postoperative pain management and postoperative nausea and vomiting are a persistent challenge for both health care providers and patients. Acupuncture is an effective and safe modality for the management of pain and nausea, and has the potential to play a key role in postoperative pain management. This study explores the utility and feasibility of acupuncture in the immediate postoperative setting. Methods: In a retrospective case–control study, 22 patients who underwent elective surgeries and received acupuncture in the post-anesthesia care unit (PACU) were compared with 88 case controls. Indications for acupuncture therapy included persistent pain, nausea, or anxiety. Patient satisfaction and symptom improvement after acupuncture were assessed. PACU nurses and patients were queried on their perspectives on using this therapy. Demographic data, perioperative opioid consumption, pain score in the PACU, incidence of postoperative nausea, PACU length of stay, and unintended hospital admission were assessed. The groups with/without acupuncture were compared using Wilcoxon rank sum test or Fisher's exact test as appropriate. Results: A total of 78.9% of patients receiving acupuncture felt improvement in their symptoms. 94.7% of recovery nurses who cared for patients who received acupuncture felt that it was helpful and 78.9% did not believe it was disruptive. Patients who opted for acupuncture had a statistically significant higher overall median (interquartile range) pain score in the PACU (7.0 [5.2, 9.5] vs. 5.0 [3.0, 7.0], p = 0.009) and higher postoperative opioid consumption (22.5 [9.8, 44.8] vs. 15.0 [0.0, 30.0], p = 0. 03). There was no difference between total perioperative opioid consumption between groups ( p = 0.94). Conclusions: Most patients who received acupuncture therapy in the PACU were satisfied with their therapy and would recommend it to future patients undergoing surgery. Most recovery nurses felt it was helpful, was not disruptive, and would like to see it utilized in the PACU.
A Comparison of Perceived Lifetime Breast Cancer Risk to Calculated Lifetime Risk Using the Gail Risk Assessment Tool
Mehta, Jaya , MacLaughlin, Kathy L. , Millstine, Denise , Wallace, Mark R. , Fields, Heather , Ruddy, Barbara E., Bryan, Michael , Golafshar, Michael A. , Millstine, Denise M, Shah, Amit A, Fields, Heather E, Bryan, Michael J, Kling, Juliana M , Golafshar, Michael , Faubion, Stephanie S. , Shah, Amit , Patel, Bhavika , Buras, Matthew , Kling, Juliana M.

Journal of Women's Health | January 18, 2022 | Volume: 31 | Issue: 3 | Pages: 356-361

10.1089/jwh.2019.8231 Get It

Background: Understanding the accuracy of a woman's perceived breast cancer risk can enhance shared decision-making about breast cancer screening through provider and patient discussion. We aim to report and compare women's perceived lifetime breast cancer risk to calculated lifetime breast cancer risk. Methods: Women presenting to Mayo Clinic in Arizona and Minnesota in July 2016 completed a survey assessing their perceived breast cancer risk. Lifetime Gail risk scores were calculated from questions pertaining to health history and were then compared with perceived breast cancer risk. Results: A total of 550 predominantly white, married, and well-educated (≥college) women completed surveys. Using lifetime Gail risk scores, 5.6% were classified as high risk (>20% lifetime risk), 7.7% were classified as intermediate risk (15%–20%), and 86.6% were classified as average risk (<15%). Of the 27 women who were classified as high risk, 18 (66.7%) underestimated their risk and of the 37 women who were intermediate risk, 12 (32.4%) underestimated risk. Women more likely to underestimate their risk had a reported history of an abnormal mammogram and at least one or more relative with a history of breast cancer. Surveyed women tended to overestimate risk 4.3 (130/30) times as often as they underestimated risk. Conclusion: In a group of predominantly white, educated, and married cohort of women, there was a large portion of women in the elevated risk groups who underestimated risk. Specific aspects of medical history were associated with underestimation including a history of abnormal mammogram and family history of breast cancer. Overall, in our sample, more women overestimated than underestimated risk.
Patient Attitudes Toward Acupuncture in the Perioperative Setting
Harbell, Monica W. , Barendrick, Lindsay N., Mi, Lanyu , Quillen, Jaxon , Millstine, Denise , Millstine, Denise M, Harbell, Monica W , Barendrick, Lindsay N.

Journal of Integrative and Complementary Medicine | January 13, 2022 | Volume: 28 | Issue: 4 | Pages: 349-354

10.1089/jicm.2021.0311 Get It

Use of a Wearable EEG Headband as a Meditation Device for Women With Newly Diagnosed Breast Cancer: A Randomized Controlled Trial
Millstine, Denise , Bhagra, Anjali , Jenkins, Sarah M. , Croghan, Ivana T. , Nguyen, Minh-Doan T., Pruthi, Sandhya , Millstine, Denise M, Stan, Daniela L., Pruthi, Sandhya , Stan, Daniela , Boughey, Judy C. , Nguyen, Minh-Doan T.

Integrative Cancer Therapies | September 30, 2019 | Volume: 18 | Issue: No issue available | Pages: No page available

10.1177/1534735419878770 Get It

Background: Breast cancer diagnosis and treatment affect quality of life and stress and are associated with fatigue. Meditation interventions are effective strategies for patients with breast cancer but are often limited by poor access, high cost, substantial time commitment, and poor adherence. In this feasibility study, we investigated the use of a portable, wearable, electroencephalographic device for guided meditation practices by breast cancer patients during the period from breast cancer diagnosis until 3 months after surgical treatment. Methods: We enrolled women (age = 20-75 years) who had received a recent diagnosis of breast cancer and planned to undergo surgical treatment. Participants were randomly assigned to perform guided meditation with the device (intervention group) or receive CD-based stress-reduction education (control group). Surveys were used to measure stress, quality of life, and fatigue at baseline, within 4 days before surgery, up to 14 days after surgery, and at 3 months after surgery. Results: In the intervention group, 15 of 17 participants (88.2%) completed the study; in the control group, 13 of 13 participants completed the study (100%). Participants in both groups had less fatigue and stress and improved quality of life at 2 weeks and 3 months after surgery compared with baseline, but there were no significant intergroup differences at any time point. Conclusion: The use of this wearable electroencephalographic device for meditation is a feasible strategy for patients with breast cancer.
Breast Cancer Screening: Women's Attitudes and Beliefs in Light of Updated United States Preventive Services Task Force and American Cancer Society Guidelines
Mehta, Jaya , MacLaughlin, Kathy L. , Millstine, Denise , Wallace, Mark R. , Shah, Amit , Fields, Heather , Ruddy, Barbara E., Bryan, Michael , Patel, Bhavika , Temkit, M’hamed , Buras, Matthew , Golafshar, Michael A. , Kling, Juliana M. , Mehta, Jaya M, Millstine, Denise M, Shah, Amit A, Fields, Heather E, Bryan, Michael J, Patel, Bhavika K , Buras, Matthew R , Golafshar, Michael , Kling, Juliana M , Shah, Amit A , Faubion, Stephanie S.

Journal of Women's Health | September 11, 2018 | Volume: 28 | Issue: 3 | Pages: 302-313

10.1089/jwh.2017.6885 Get It

Integrative Medicine Preferences Among Coccidioidomycosis (Valley Fever) Patients
Short, Jack H., Bradley, Constance, Blair, Janis E. , Stewart, Terry D., Burns, Mark W. , Patron, Roberto L. , Millstine, Denise , Millstine, Denise M

The Journal of Alternative and Complementary Medicine: Paradigm, Practice, and Policy Advancing Integrative Health | August 24, 2016 | Volume: 23 | Issue: 2 | Pages: 135-139

10.1089/acm.2016.0139 Get It

Objectives: To understand the extent and modalities of integrative medicine strategies that patients with coccidioidomycosis (valley fever) have incorporated into their treatment regimens. Design: A direct patient survey was distributed, with 100 unique responses, at a single infectious diseases clinic at an academic medical center in Arizona. Eligible patients, defined as those with confirmed coccidioidomycosis or currently under evaluation, were polled on their personal use of 36 integrative medicine modalities. Patients were also asked to indicate their level of fatigue on a 10-point scale in an attempt to correlate levels of fatigue to use of specific integrative medicine modalities. Results: Of the patients surveyed, 64% had used at least one integrative medicine modality, and 53% used two or more, along with conventional medical therapy. The top three modalities were nutrition (39%), massage (27%), and breathing exercises (26%). The mean reported fatigue level was 4.7 on a 10-point scale, with a standard deviation of 3.0. There was no statistically significant association between use of a specific modality and reported level of fatigue. Conclusions: Nearly two thirds of patients (64%) surveyed had used at least one integrative medicine modality throughout the course of their therapy. Clinicians are probably unaware of the extent to which many patients, including this population, have embraced integrative medicine. Awareness of patients' goal and preferences is valuable in shared clinical decision making.
Heavy Metal? Recognizing Complications of Metal on Metal Hip Arthroplasty
Millstine, Denise , Hakes, Hannah J., Mayer, Anita P. , Millstine, Denise M, Spangehl, Mark J.

Journal of Women's Health | June 16, 2014 | Volume: 23 | Issue: 9 | Pages: 777-779

10.1089/jwh.2014.4868 Get It