Wang, Liang
Mayo Clinic
2Departments of Laboratory Medicine and Pathology,
Citations 1
Mitochondrial Genetic Polymorphisms Do Not Predict Survival in Patients with Pancreatic Cancer
Hálfdánarson, Þorvarður R. , Bamlet, William R. , Cunningham, Julie M. , Petersen, Gloria M. , Wang, Liang , Andrade, Mariza de , McWilliams, Robert R. , Halfdanarson, Thorvardur R , Bamlet, William R
Cancer Epidemiology, Biomarkers & Prevention | September 3, 2008 | Volume: 17 | Issue: 9 | Pages: 2512-2513
Abstract Pancreatic cancer is a highly lethal malignancy, and the majority of patients succumb to the disease within 2 years. We evaluated the role of variants of mitochondrial DNA and mitochondrial haplogroups in predicting prognosis of patients with pancreatic cancer. A total of 24 mitochondrial single nucleotide polymorphisms were genotyped in 990 patients with pancreatic cancer. After adjusting for covariates and multiple comparisons, no association between any of the mitochondrial single nucleotide polymorphisms or haplogroups and survival was observed. (Cancer Epidemiol Biomarkers Prev 2008;17(9):2512–3)