Citations 1
Multiomic characterization of DNA released after airway exposure to allergens and nanoparticles reveals selective export of repetitive and fragile site DNA
Law, Kayla , Srisomboon, Yotesawee, Iijima, Koji, Faulk, Christopher , Kita, Hirohito , O’Grady, Scott M. , Kita, H
Physiological Genomics | July 13, 2026 | Volume: 58 | Issue: 8 | Pages: 382-393
10.1152/physiolgenomics.00029.2026
Exposure of airway epithelia to environmental allergens or nanoparticles invokes a novel genome-protective physiological response to oxidative stress. Fragments of double-stranded genomic DNA released into the airway lumen originate from repetitive, transcriptionally active, and fragile sites within the genome. Exporting DNA with high repetitive content potentially aids cell survival through the preservation of genome integrity and fidelity during the repair process.