Citations 2
Unsatisfactory Reporting Rates: 2006 Practices of Participants in the College of American Pathologists Interlaboratory Comparison Program in Gynecologic Cytology
Moriarty, Ann , Clayton, Amy C., Zaleski, Sue, Henry, Michael , Schwartz, Mary R. , Eversole, Galen M., Tench, William D., Fatheree, Lisa A., Souers, Rhona J., Wilbur, David C.
Archives of Pathology & Laboratory Medicine | February 12, 2021 | Volume: 133 | Issue: 12 | Pages: 1912-1916
Abstract Context.—Minimum cellular criteria for satisfactory Papanicolaou tests were established with the Bethesda System in 2001, and unsatisfactory rates are used as a quality-reporting measure. Objective.—To evaluate practices and unsatisfactory rates from laboratories responding to the 2007 College of American Pathologists supplemental questionnaire survey. Design.—In 2007, a supplemental questionnaire was mailed to 1621 laboratories enrolled in the 2006 College of American Pathologists Interlaboratory Comparison Program in Gynecologic Cytology (PAP Education), requesting data from the 2006 calendar year. Unsatisfactory rates, reasons for unsatisfactory specimens, laboratory size, and specimen preparation type were analyzed. Results.—A total of 42% of the laboratories responded to the survey. Most of those laboratories (637 of 674; 94.5%) used the Bethesda System minimum cellularity criteria. Of those laboratories responding, 79% (527 of 667) used the Bethesda System criteria for atrophic or postirradiation specimens. Unsatisfactory rates have increased since 1996. SurePath preparations were associated with the lowest unsatisfactory rate (50th percentile, 0.30; 95th percentile, 1.3), conventional Papanicolaou tests had the highest 95th percentile rates (50th percentile, 1.0; 95th percentile, 5.90), and ThinPrep specimens had the highest median percentile (50th percentile, 1.1; 95th percentile, 3.4). The most-common reason for unsatisfactory Papanicolaou tests was too few squamous cells. Air-drying artifact was the least-common reason for unsatisfactory reporting for liquid-based preparations. Conclusions.—Use of the Bethesda System criteria for unsatisfactory specimens is widespread. Unsatisfactory rates have increased since 1996; however, the median rates are 1.1% or less for all preparations. Results from the College of American Pathologists PAP Education supplemental questionnaire continue to provide valuable benchmarking data for cytologic quality-improvement programs in laboratories.
The Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions: Background and Consensus Recommendations from the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology
Darragh, Teresa M. , Colgan, Terence J. , Cox, J. Thomas, Heller, Debra S. , Henry, Michael , Luff, Ronald D., McCalmont, Timothy H. , Nayar, Ritu , Stoler, Mark H. , Wilkinson, Edward J., Zaino, Richard J., Wilbur, David C. , Luff, Ronald D., Wilkinson, Edward J., Wilkinson, Edward J., O’Connor, Dennis M., Reynolds, R. Kevin, Selim, M. Angélica , Scurry, James , Chelmow, David , Howell, Lydia, Ronnett, Brigitte M., Waxman, Alan G., Haefner, Hope K. , Leslie, Kieron , Lytwyn, Alice, Winkler, Barbara , Colgan, Terence J., Downs, Levi S., Laucirica, Rodolfo, Allbritton, Jill, Ioffe, Olga B. , Joste, Nancy E., Berry, J. Michael, Lin, Oscar , Welton, Mark L., Otis, Christopher N. , Stoler, Mark H. , Bentz, Joel S., Quade, Bradley J. , Schwartz, Mary R. , Luff, Ronald D., Castle, Philip E. , García, Francisco , Moriarty, Ann , Niedt, Greg , Carter, Alicia , Neal, Margaret B., Reddy, Vijaya , Robboy, Stanley J. , Spires, Susan E., Luff, Ronald D., Palefsky, Joel Michael , Wilkinson, Edward J., Wilkinson, Edward J., Shea, Christopher Michael , Staats, Paul N. , Roberts, Jennifer Margaret , Colgan, Terence J., Kong, Christina S. , Luff, Ronald D., Duggan, Máire A. , Goodman, Marc T. , Saraiya, Mona , Silverberg, Steven M.
Archives of Pathology & Laboratory Medicine | June 28, 2012 | Volume: 136 | Issue: 10 | Pages: 1266-1297
Abstract The terminology for human papillomavirus (HPV)–associated squamous lesions of the lower anogenital tract has a long history marked by disparate diagnostic terms derived from multiple specialties. It often does not reflect current knowledge of HPV biology and pathogenesis. A consensus process was convened to recommend terminology unified across lower anogenital sites. The goal was to create a histopathologic nomenclature system that reflects current knowledge of HPV biology, optimally uses available biomarkers, and facilitates clear communication across different medical specialties. The Lower Anogenital Squamous Terminology (LAST) Project was cosponsored by the College of American Pathologists and the American Society for Colposcopy and Cervical Pathology and included 5 working groups; 3 work groups performed comprehensive literature reviews and developed draft recommendations. Another work group provided the historical background and the fifth will continue to foster implementation of the LAST recommendations. After an open comment period, the draft recommendations were presented at a consensus conference attended by LAST work group members, advisors, and representatives from 35 stakeholder organizations including professional societies and government agencies. Recommendations were finalized and voted on at the consensus meeting. The final, approved recommendations standardize biologically relevant histopathologic terminology for HPV-associated squamous intraepithelial lesions and superficially invasive squamous carcinomas across all lower anogenital tract sites and detail the appropriate use of specific biomarkers to clarify histologic interpretations and enhance diagnostic accuracy. A plan for disseminating and monitoring recommendation implementation in the practicing community was also developed. The implemented recommendations will facilitate communication between pathologists and their clinical colleagues and improve accuracy of histologic diagnosis with the ultimate goal of providing optimal patient care.