Citations 1
Arteriovenous fistula creation results in cardiac dysfunction and remodeling in a uremic pig model
Kane, Jamie , Baranwal, Gaurav , Roy-Chowdhury, Shreya , Naskar, Atanu , Montonye, Dan , Lutgens, Esther , Wang, Ying , Negm, Ahmed , Singh, Prabh G , Kilari, Sreenivasulu , Baranwal, Gaurav , Roy-Chowdhury, Shreya , Naskar, Atanu , Montonye, Dan , Lutgens, Esther , Wang, Ying , Negm, Ahmed S , Collins, Jeremy , Lee, Timmy , Misra, Sanjay , Kane, Jamie , Singh, Prabh G. , Collins, Jeremy D.
American Journal of Physiology-Renal Physiology | May 19, 2026 | Volume: 330 | Issue: 6 | Pages: F783-F795
The creation of an arteriovenous fistula in a uremic pig induces cardiac remodeling, which resembles contemporary clinical findings in patients with end-stage kidney disease (ESKD) and includes increased end-diastolic volumes and cardiomyocyte hypertrophy, potentially driven by fibrosis and senescence. This novel large animal model may now enable mechanistic and therapeutic studies aiming to ease the unacceptably high burden of cardiovascular disease on patients with ESKD.