Citations 1
An Enhanced Treatment Algorithm Targeting Mucosal Healing Is Effective and Safe in Older Patients With Crohn's Disease: A Post Hoc Analysis of the REACT2 Trial
Goodwin, Shane W. , Vuyyuru, Sudheer K. , Sedaño, Rocío , Zou, Guangyong, Dulai, Parambir S., Singh, Siddharth , Narula, Neeraj, Ma, Christopher, Jairath, Vipul, Zou, Guangyong , Ma, Christopher , Vuyyuru, Sudheer Kumar , Zou, Guangyong , Dulai, Parambir S , Singh, S , Narula, Neeraj , Ma, C , Sedano, Rocio , Dulai, Parambir S. , Narula, Neeraj , Jairath, Vipul
American Journal of Gastroenterology | April 3, 2026 | Volume: No volume available | Issue: No issue available | Pages: No page available
INTRODUCTION: Safety and effectiveness of treating to target mucosal healing in older patients with Crohn's disease (CD) is unknown. METHODS: We analyzed CD-related complications by 24 months in the randomized evaluation of an algorithm for Crohn's treatment—study 2-2 trial that randomized practices to an enhanced-care or step-care algorithm to determine whether patient age modifies the effect of treatment. Data were analyzed using marginal Cox regression and modified Poisson regression. RESULTS: There was no difference in treatment between younger and older patients in at 24 months. DISCUSSION: Enhanced-care was effective and not associated with increased risk compared with step-care in older patients with CD.