Citations 1
Establishment and characterization of multiple myeloma cell lines from a single patient’s disease course immortalizes clonal heterogeneity
Bergsagel, P. Leif, Wiedmeier-Nutor, Julia E., Stein, Caleb K. , Mangalaparthi, Kiran K. , Brown, Sochilt , Shotts, Yuliza, Aguirre, Juana Fiueroa, Asmann, Yan W. , Fonseca, Rafael, Chesi, Marta , Bergsagel, P. Leif , Bergsagel, P. Leif , Stein, Caleb K , Riggs, Daniel L. , Kandasamy, Richard K. , Franke, Karl , Braggio, Esteban , Fonseca, Rafaël , Pandey, Akhilesh
No container title available | March 12, 2026 | Volume: No volume available | Issue: No issue available | Pages: No page available
Abstract Multiple myeloma (MM) is an incurable plasma cell neoplasm characterized by diverse and complex genetic abnormalities, including translocations of immunoglobulin (Ig) genes and a hyperdiploid (HRD) karyotype. Much of our current understanding of MM genetics, epigenetics, pathogenesis and response/resistance to myeloma directed therapies originated from studies on human MM-derived cell lines (HMCL). In this study, we conducted an integrated multi-omics analysis in five hyperdiploid cell lines established from serial samples from a single relapsed/refractory hyperdiploid MM patient, enabling detailed characterization of the genetic landscape and molecular alterations through disease progression.