Citations 1
Vascular transcriptional and metabolic changes precede progressive intrarenal microvascular rarefaction in autosomal dominant polycystic kidney disease
Yilmaz, Gizem, Singha, Santu K., Savaliya, Bansi, Abdelfattah, Ahmed, Elsekaily, Walaa , Xu, Xiaohong , Zhang, Y., Hanna, Christian , Hogan, Marie C. , Chade, Alejandro , Eirin, Alfonso, Abd-Elfattah, Ahmed Saleh , Abdelfattah, Ahmed , Zhang, Youwen, Eirin, Alfonso , Irazabal, Maria V , Hanna, Christian , Hogan, Marie C , Eirin, Alfonso , Irazabal, María V.
American Journal of Physiology-Renal Physiology | February 5, 2026 | Volume: 330 | Issue: 3 | Pages: F326-F345
We provide the first longitudinal and most comprehensive analysis of the intrarenal microvasculature in a slowly progressive model of autosomal dominant polycystic kidney disease (ADPKD) and integrate the findings with studies in a young cohort of individuals with ADPKD. We identified vasculature-related pathways that could be targeted for therapeutic interventions and contribute promising, noninvasive biomarkers in patients with ADPKD. Alterations of the intrarenal microcirculation may affect drug delivery; a better understanding of its longitudinal changes may aid in treatment management.