Sánchez‐Valle, Raquel
Mayo Clinic
Biomedical Research Networking Center on Neurodegenerative Diseases
Citations 1
Relationship between locus coeruleus and slow‐wave sleep in aging and Alzheimer's disease
Falgàs, Neus , Tort‐Colet, Núria, Martín‐Sobrino, Isabel, Mayà, G., Peña‐González, Marta, Rudilosso, Salvatore , Gaig, Carles, Arqueros, Aurora, Piñol‐Ripoll, Gerard, Balasa, Mircea, Lladó, Albert, Ruiz, M. Morales, Muñoz‐Moreno, Emma, Grau‐Rivera, Oriol, Iranzo, Alex, Grinberg, Lea T., Sánchez‐Valle, Raquel, Tort‐Colet, Núria , Martín-Sobrino, Isabel , Mayà, Gerard , Gaig, Carles , Bosch, Beatríz , Pérez‐Millan, Agnès , Tort‐Merino, Adrià , Fernández‐Villullas, Guadalupe , Piñol‐Ripoll, Gerard , Balasa, Mircea , Lladó, Albert , Muñoz‐Moreno, Emma , Grau‐Rivera, Oriol , Iranzo, Álex , Sánchez‐Valle, Raquel
Alzheimer's & Dementia | February 3, 2026 | Volume: 22 | Issue: 2 | Pages: No page available
Abstract INTRODUCTION Sleep disruption, particularly loss of slow‐wave sleep (SWS), is common in Alzheimer's disease (AD), but its neurobiological underpinnings remain unclear. We investigated whether locus coeruleus (LC) integrity relates to SWS across the AD continuum and whether sex and perivascular spaces (PVSs) modify these associations. METHODS In a cohort (11 controls, 30 mild cognitive impairment, 17 AD dementia) we combined overnight polysomnography with LC‐sensitive magnetic resonance imaging of the LC, basal ganglia and centrum semiovale PVS ratings, and cerebrospinal fluid noradrenaline. Multivariable linear regression adjusted for demographics, disease stage, and medication use. RESULTS Higher LC integrity was associated with greater slow‐wave activity and slow oscillation power, with stronger effects in females. Basal ganglia PVS burden was related to lower SWS spectral power, whereas noradrenaline levels were not associated with sleep. DISCUSSION LC integrity, sex, and PVS burden show associations with SWS alterations in aging and AD, supporting restorative sleep as a potential therapeutic target.