Citations 2
The landscape of dementia research, diagnosis, treatment, and care in Latin America
Suemoto, Claudia K., Custodio, Nilton, Avila‐Funes, José A., Baez, Sandra, Bagnati, Pablo , Barnes, Lisa Laverne, D., Brucki Sonia M., Calandri, Ismael L., Cornejo‐Olivas, Mario, Derio, Carolina Delgado, García, Adolfo M., Grinberg, Lea T., Ibanez, Agustin M., Isasi, Rosario, Josephy‐Hernandez, Sylvia , Porras, Maria Lazo, Llibre‐Guerra, Jorge J., Llibre‐Rodriguez, Juan J., Meza, B. Marcela Mar, Migeot, Joaquin, Miranda, J. Jaime, Miranda‐Castillo, Claudia, Mummery, Catherine J., Parodi, José F., Castro, Natalia Pozo, Contreras, Rosa María Salinas, Slachevsky, Andrea, Souza‐Talarico, Juliana Nery, Takada, Leonel T., Tsoy, Elena, Pilalumbo, Martha Unaucho, Zimmer, Eduardo R., Fontana, Igor C. , Snyder, Heather M. , Carrillo, Marı́a C., Carrillo, María C. , Takada, Leonel Tadao , Custodio, Nilton , Ibáñez, Agustín , Suemoto, Cláudia Kimie , Delgado, Carolina , Mahinrad, Simin , Ibañez, Agustín , Suemoto, Claudia Kimie , Aguilar, Diego, Ávila‐Funes, José Alberto , Báez, Sandra , Barnes, Lisa L. , Brucki, Sônia Maria Dozzi , Caramelli, Paulo , Cornejo-Olivas, Mario , Ferreira, Sérgio T. , García, A.R. , Grinberg, Lea T. , Llibre‐Guerra, Jorge J. , Rodríguez, Juan J. Llibre , Lourenco, Mychael V. , Migeot, Joaquín , Miranda, J. Jaime , Miranda‐Castillo, Claudia , Mummery, Catherine J. , Parodi, Jose Francisco , Salinas‐Contreras, Rosa Maria, Santamaría‐García, Hernando A , Slachevsky, Andrea , Souza‐Talarico, Juliana Nery , Surace, Ezequiel , Tsoy, Elena , Unaucho‐Pilalumbo, Martha , Zimmer, Eduardo Rigon , Mahinrad, Simin
Alzheimer's & Dementia | March 27, 2026 | Volume: 22 | Issue: 3 | Pages: No page available
Abstract Latin America is undergoing rapid population aging alongside a rising burden of dementia. While the region holds substantial potential for dementia risk reduction, challenges remain, such as delayed diagnoses, limited access to specialized care and biomarker testing, persistent stigma, and deep‐rooted structural inequities. To address these gaps and foster regionally informed solutions, the Alzheimer's Association convened the 2025 Alzheimer's Association International Conference (AAIC) Satellite Symposium in Lima, Peru, on May 14–15, in collaboration with the Global Brain Health Institute (GBHI) and the Atlantic Fellows for Equity in Brain Health. The meeting aimed to bring core elements of the global AAIC meeting to regional Latin American settings, recognizing that national and cultural contexts demand tailored approaches to dementia prevention, risk reduction, treatment and care all aimed at promoting brain health in the region. This manuscript synthesizes the symposium's key discussions, scientific advances, and opportunities for collaboration across the region.
Multi‐omic expression of the VEGF family relates to Alzheimer's disease across diverse populations
Libby, Julia B. , Deters, Kacie D., Ertekin‐Taner, Nilüfer, Carrasquillo, Minerva M., Allen, Mariet , Jager, Philip De, Menon, Vilas, Zhang, Bin, Haroutunian, Vahram , Levey, Allan I., Seyfried, Nicholas T., Kaddurah‐Daouk, Rima, Finkbeiner, Steve, Wang, F., Linden, Abby Vander , Poehlman, William L. , Dumitrescu, Logan, Petyuk, Vladislav A., Bennett, David A., Schneider, Julie A., Barnes, Lisa Laverne, Deters, Kacie, Ertekin‐Taner, Nilüfer , Carrasquillo, Minerva M. , Jager, Philip L. De , Menon, Vilas , Zhang, Bin, Levey, Allan I. , Seyfried, Nicholas T. , Kaddurah‐Daouk, Rima , Finkbeiner, Steven , Wang, Daifeng, Greenwood, Anna K., Heath, Laura , Dumitrescu, Logan , Petyuk, Vladislav , Bennett, David A. , Schneider, Julie A. , Barnes, Lisa L. , Hohman, Timothy J.
Alzheimer's & Dementia | January 28, 2026 | Volume: 22 | Issue: 1 | Pages: No page available
Abstract INTRODUCTION The vascular endothelial growth factor (VEGF) signaling family plays a role in neurodegenerative diseases, including Alzheimer's disease (AD). Previous work has shown widespread effects of the members FLT1 , FLT4 , and VEGFB on AD outcomes. However, these analyses have focused within the non‐Hispanic White (NHW) population. METHODS The goal of this study was to analyze the effects of the VEGF family in underrepresented populations, leveraging large and diverse bulk RNA sequencing and tandem mass tag–mass spectrometry (TMT‐MS) proteomic data. Outcomes included measures of AD pathology and diagnosis. RESULTS Within underrepresented populations, we replicated previously reported effects of FLT1 and FLT4 , whereby higher protein abundance was observed in the AD brain and was associated with higher neuropathology burden. In stratified analyses, these associations were largely consistent across race and ethnicity. DISCUSSION This multi‐omic study on the role of the VEGF family in AD emphasizes the need for more representative studies focused on therapeutic targets for AD. Highlights Vascular endothelial growth factor (VEGF) genes and proteins were quantified in four different brain regions. Samples included participants from four different populations. Previously observed effects were replicated in diverse populations. This study is the largest multi‐omic study of the vascular endothelial growth factor (VEGF) genes among Alzheimer's disease (AD) participants from diverse populations.