Citations 1
Alignment of Molecular Classification Between Diagnosis and Recurrence in Endometrial Cancer: Lessons from a Single-Institution Experience to Inform Future Pathways
RESTAINO, Stefano, Pellecchia, Giulia , Arcieri, Martina , Mariuzzi, Laura , Orsaria, Maria , Tulisso, Angelica , Cesselli, D., Bulfoni, M., Poli, Alice , Paparcura, Federico , Bogani, Giorgio, Mariani, Andrea, Zannoni, Gianfranco, Scambia, G., Vizzielli, Giuseppe, Bogani, Giorgio , Vizzielli, Giuseppe , Restaino, Stefano , Restaino, Stefano , Cesselli, Daniela , Bulfoni, Michela , Bogani, Giorgio , Vizzielli, Giuseppe , Poli, Alice , Mariani, Andrea
Cancers | January 13, 2026 | Volume: 18 | Issue: 2 | Pages: 247
Introduction: Endometrial carcinoma (EC) is the most prevalent gynecological cancer. It is characterized by a clinical, pathological, and prognostic trajectory that has become inextricably linked to the disease’s molecular profile. Therefore, it is imperative to examine its relevance across all facets associated with the disease. Methods: This is a single-center retrospective study to assess tumor molecular profile concordance between EC diagnosis and recurrence. All patients who underwent hysterectomy for EC between 2016 and 2020 were included. Results: In total, 221 cases of EC were collected. In total, 18 recurrences were found. In two cases, there was a molecular classification (MC) change: an MMR-deficient endometrioid EC shifted to a “multiple classifier” subtype. The second, an NSMP subtype, at second recurrence revealed a switched MC to an aberrant mutated p53 profile. This discordance rate was non-significant in our cohort. However, considering the lack of evidence, it opens new insights to be revealed. Conclusions: This is the first study focusing on the discordance rate of MCs in EC relapses compared to the initial diagnosis. Future large-scale retrospective and prospective multicenter studies are essential for exploring this aspect.