Back to Authors

Misganaw, Burook

0000-0002-9569-1662

Mayo Clinic

Walter Reed Army Institute of Research

Citations 1

Multiomics alterations associated with tolerance and response to simulated progressive hemorrhage in healthy adult humans
Misganaw, Burook , Muhie, Seid , Gautam, Aarti , Miller, Stacy-Ann, Rosales, I. C. Bonilla, Dimitrov, George I., Sowe, Bintu, Johnson, Christopher P., Roberts, Shelly K., Regimbal, Riley J. , Wiggins, Chad C. , CONVERTINO, V, Joyner, Michael J , Curry, Timothy B. , Hammamieh, Rasha , Wiggins, Chad C , Gautam, Aarti, Miller, Stacy‐Ann , Dimitrov, George I., Johnson, Christopher P., Joyner, Michael J. , Convertino, Víctor A.

Physiological Genomics | January 7, 2026 | Volume: 58 | Issue: 2 | Pages: 102-114

10.1152/physiolgenomics.00253.2025 Get It

This study investigated the first multiomics data for association with tolerance to central hypovolemia in humans. Analyzing gene expression, proteins, and genetic variants in individuals with high and low tolerance to simulated hemorrhage, the findings show that severe blood loss causes widespread transcriptional changes, including the activation of innate immune system pathways and inhibition of gas transport processes. This research can help identify molecular factors that influence individuals’ tolerance levels for progressive blood loss.