Citations 1
Treatment Approaches for Obesity in Children With Heterozygous MC4R Variants
Salama, Mostafa , Saba, Leslie , Valdez, Lourdes, Lteif, Aida, Kumar, Seema, Saba, Leslie , Salama, Mostafa , Valdez, Lourdes
Clinical Obesity | January 5, 2026 | Volume: 16 | Issue: 1 | Pages: No page available
ABSTRACT Melanocortin‐4 receptor (MC4R) deficiency is the most common cause of monogenic obesity; yet treatment options for children with MC4R mutations are limited. We describe significant improvement in weight in three patients with pathogenic or likely pathogenic MC4R mutations; two adolescents treated with semaglutide, and a younger child treated with metformin and topiramate. These findings indicate GLP‐1 receptor agonists, topiramate and metformin can be helpful in managing obesity associated with MC4R deficiency.