Citations 2
Imaging the later‐life white matter pathologies of repetitive head impacts: A novel pattern revealed through T2 FLAIR MRI
Groh, Jenna R. , Miner, Annalise E., Alshikho, Mohamad J. , Farris, Chad, Cui, Anna, Pettway, Erika, Labonte, Jacob , Mosaheb, Sydney, Tripodis, Yorghos, Adler, Charles H., Balcer, Laura J. , Bernick, Charles, Cantu, Robert C., Dodick, David W., Ashton, Nicholas J., Zetterberg, Henrik, Blennow, Kaj, Peskind, Elaine R. , Nowinski, Christopher, Lenio, Steven, Rabinovici, Gil D., Asken, Breton, Rosen, Howard, Blusztajn, Jan Krzysztof , Budson, Andrew E., Turk, Katherine, Goldstein, Lee, Martin, Brett, Palmisano, Joseph N., Dixon, Diane, Schneider, Greta, Steinberg, Eric G., Su, Yi, Protas, Hillary , Pasternak, Ofer, Bouix, Sylvain, Cummings, Jeffrey L., Reiman, Eric M., Shenton, Martha E., Stern, Robert A., McKee, Ann C., Stein, Thor D., Brickman, Adam M., Mez, Jesse, Alosco, Michael L., Rabinovici, Gil D. , Rabinovici, Gil D , Miner, Annalise E., Farris, Chad W. , Cui, Anna, Pettway, Erika C, Tripodis, Yorghos , Adler, Charles H. , Bernick, Charles , Cantu, Robert C. , Coleman, Michael , Dodick, David W. , Ashton, Nicholas J. , Zetterberg, Henrik , Blennow, Kaj , Ly, Monica T. , Altaras, Caroline , Lenio, Steven , Asken, Breton M. , Cobigo, Yann , Budson, Andrew E. , Turk, Katherine W. , Qiu, Wei Qiao , Palmisano, Joseph , Steinberg, Eric G. , Pasternak, Ofer , Koerte, Inga K , Bouix, Sylvain , Reiman, Eric M. , Shenton, Martha E. , McKee, Ann C. , Stein, Thor D. , Brickman, Adam M. , Mez, Jesse , Alosco, Michael L.
Alzheimer's & Dementia | April 20, 2026 | Volume: 22 | Issue: 4 | Pages: No page available
Abstract INTRODUCTION Repetitive head impacts (RHI) from contact sports may cause a unique pattern of white matter hyperintensities (WMH) on T2‐weighted fluid‐attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI), termed RHI‐associated WMH (RHI‐WMH). These lesions are punctate, circular, and located at the gray–white matter boundary, an area vulnerable to trauma‐related damage. METHODS We investigated the association of RHI with these lesions in two aging cohorts: (1) former American football players versus asymptomatic unexposed men and (2) individuals with RHI from various contact sports versus non‐RHI participants. RHI‐WMH were assessed using visual ratings and a novel automated quantification pipeline. RESULTS Individuals with RHI had greater RHI‐WMH by both detection methods in both cohorts. RHI‐WMH were associated with plasma neurofilament light and p‐tau231, and flortaucipir positron emission tomography (PET) uptake. DISCUSSION RHI‐WMH may represent a new supportive biomarker for the detection of RHI‐related neuropathologies later in life.
Clinicopathological study of chronic traumatic encephalopathy pathology in a population-based cohort
Rodriguez, Roberta Diehl, Nowinski, Christopher, Suemoto, Cláudia Kimie , Leite, Renata Elaine P, Ferretti-Rebustini, Renata Eloah de Lucena, Jacob-Filho, Wilson, Pasqualucci, Carlos Augusto, Nitrini, Ricardo, Grinberg, Lea T, Grinberg, Lea T. , Grinberg, Lea , Suemoto, Claudia Kimie , Leite, Renata Elaine Paraizo , Rodriguez, Roberta Diehl , Ferretti‐Rebustini, Renata Eloah de Lucena , Jacob-Filho, Wilson, Pasqualucci, Carlos Augusto , Nitríni, Ricardo
Journal of Neuropathology & Experimental Neurology | November 28, 2025 | Volume: 85 | Issue: 5 | Pages: 425-432
Abstract Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease linked to repetitive traumatic brain injury, but its prevalence and risk factors in the general population remain poorly defined. We investigated CTE neuropathological changes (CTE-NC) in an admixed, population-based clinicopathological cohort. Neuropathological evaluation was conducted on brain samples from 1151 individuals in the University of São Paulo Biobank for Aging Studies collected from 2004 to 2022. CTE-NC and aging-related tau astrogliopathy (ARTAG) were assessed across 14 963 histological slides using p-tau immunostaining. Clinical, cognitive, and neuropsychiatric data were obtained via informant interviews; information on sports exposure and traumatic brain injury history was limited. Seven cases (0.6%) met criteria for CTE-NC, mean age at death 73.4 ± 12.5 years; 1 was female. Dementia was present in 43% of CTE-NC cases; 57% exhibited neuropsychiatric symptoms. Most common co-pathologies were Alzheimer disease-type changes, ARTAG, and argyrophilic grain disease. Comprehensive exposure histories were unavailable for most cases; 2 had documented soccer involvement. These findings indicate that CTE-NC is rare in this population-based Brazilian cohort and predominantly affects males with frequent coexisting neuropathologies. Findings align with reports from high-income countries and support prioritizing primary prevention by reducing exposure to repetitive head impacts in sport and other settings.