Citations 3
Diagnostic utility of immunofixation and free light chain assay in AL amyloidosis: a systematic review and meta-analysis
Azzam, Muayad , Hamarsha, Qais , Kawtharany, Hassan , Nazzal, Jamil, Alkhader, Aseel, Khraise, Tala, AlMasri, Mohammad M., Zeid, Hadi K. Abou, Alwan, Iktimal, Jaber, Nour, Seftel, Matthew D. , Aguirre, M A, Boedicker, Deborah , Bumma, Naresh , Comenzo, Raymond, Dasgupta, Noel R, Torre, Alfredo De La, Jamal, Faizi , Khouri, Jack , Raza, Shahzad, Sarswat, Nitasha , Shaikh, Hira , Singh, Daulath , Kukreti, Vishal, Zeid, Hadi Khaled Abou , Aguirre, María Adela , Abou Zeid, Hadi Khaled , Aguirre, Maria Adela , Carroll, Antonia S , Cook, Joselle M , Dispenzieri, Angela , Jamal, Faizi , Khouri, Jack , Picken, Maria M. , Leung, Nelson , Sanchorawala, Vaishali , Sarswat, Nitasha , Mustafa, Reem A , Kawtharany, Hassan , Shaikh, Hira , Carroll, Antonia , Comenzo, Raymond L. , Cook, Joselle , Dispenzieri, Angela , Raza, Shahzad, Leung, Nelson , Kukreti, Vishal
Blood Advances | April 14, 2026 | Volume: 10 | Issue: 15 | Pages: 5293-5307
10.1182/bloodadvances.2025019530
Abstract In this systematic review, we aimed to assess the sensitivity of serum immunofixation (SIFE), urine immunofixation (UIFE), and serum free light chain (sFLC) in detecting plasma cell dyscrasia associated with light chain (AL) amyloidosis. We searched the literature using PubMed, Embase, and CENTRAL databases since inception through March 2024. We included studies reporting the diagnostic accuracy of immunofixation and/or sFLC in patients with AL amyloidosis. We used the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) approach to assess the certainty of the evidence and QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies-2) to assess the risk of bias. After deduplication, 29 237 records were screened, and 44 studies (n = 18 071) were included. For the meta-analysis, 28 studies reported sensitivity for SIFE (n = 3390), 24 studies for UIFE (n = 2830), 19 studies for SIFE and UIFE (n = 2819), 21 studies for sFLC ratio (n = 3678), 6 studies for SIFE and sFLC ratio (n = 372), 3 studies for UIFE and sFLC ratio (n = 242), and 10 studies for all 3 tests (n = 1430). Pooled sensitivities were as follows: SIFE, 0.68 (95% confidence interval [CI], 0.62-0.73); UIFE, 0.77 (95% CI, 0.72-0.81); SIFE and UIFE, 0.89 (95% CI, 0.84-0.93); and sFLC ratio, 0.82 (95% CI, 0.78-0.86). When SIFE, UIFE, and sFLC ratio were combined, the sensitivity reached 0.99 (95% CI, 0.96-1.00). The high sensitivity of combining SIFE, UIFE, and sFLC ratio supports their use as a reliable initial testing strategy to raise suspicion for AL amyloidosis and guide decisions regarding future diagnostic modalities.
The role of cardiac imaging for diagnosis of cardiac amyloidosis: a systematic review and meta-analysis of test accuracy
Kawtharany, Hassan , Nazzal, Jamil, Hamarsha, Qais , Alkhader, Aseel, Khraise, Tala, Al-Masri, Mahmoud , Zeid, Hadi K. Abou, Alwan, Iktimal, Jaber, Nour, Jamal, Faizi , Dasgupta, Noel R., Sarswat, Nitasha, Torre, Alfredo H. De La, Aguirre, Maria Adela, Boedicker, Deborah , Bumma, Naresh , Comenzo, Raymond, Cook, Joselle, Dispenzieri, Angela, Khouri, Jack , Raza, Shahzad, Leung, Nelson, Shaikh, Hira, Singh, Daulath, Seftel, Matthew D. , Kukreti, Vishal , Shaikh, Hira , Aguirre, María Adela , K Abou Zeid, Hadi, Sarswat, Nitasha , Dispenzieri, Angela , Sanchorawala, Vaishali , Aguirre, Maria Adela , Kawtharany, Hassan , Shaikh, Hira , Azzam, Muayad , Zeid, Hadi Khaled Abou , Alzabibi, Mhd Amin , Sarswat, Nitasha , Torre, Alfredo H. De La, Carroll, Antonia , Comenzo, Raymond L. , Cook, Joselle, Dispenzieri, Angela , Picken, Maria M. , Leung, Nelson , Mustafa, Reem A
Amyloid | January 2, 2026 | Volume: 33 | Issue: 1 | Pages: 59-71
Gastrojejunal Anastomosis Adenocarcinoma Occurring After Trans-Oral Revision for Weight Recurrence After Roux-en-Y Gastric Bypass
Salameh, Yara , Zeid, Hadi K. Abou, Gala, Khushboo , Kumari, Roopa, Abou Zeid, Hadi K, Gala, Khushboo S, Salameh, Yara , Zeid, Hadi Khaled Abou , Storm, Andrew C.
ACG Case Reports Journal | July 18, 2025 | Volume: 12 | Issue: 7 | Pages: e01775
ABSTRACT Weight recurrence is a late complication after Roux-en-Y gastric bypass. The transoral outlet reduction (TORe) emerged as an endoscopic alternative to revisional surgery for weight recurrence due to a dilated and incompetent gastrojejunal anastomosis. The procedure has been documented as safe and effective in clinical trials and other high-quality medical literature. Several cases of squamous metaplasia of the gastric pouch after repeated TORe procedures using argon plasma coagulation have been reported. We present a case of a late-onset adenocarcinoma of the gastrojejunal anastomosis after a TORe procedure performed using argon plasma coagulation and suturing.