Citations 1
The Society of Pediatric Liver Transplantation ( SPLIT ): 2023 Registry Status
Banc‐Husu, Anna M. , Smith, Rachel , Kelly, Beau , Anand, Ravinder , Anderson, Sarah G. , Lobritto, Steven , Chapin, Catherine A. , Chartier, Marie‐Eve , Ekong, Udeme D. , Furuya, Katryn N. , García, Jennifer , González‐Peralta, Regino P. , Ibrahim, Samar H. , Kerkar, Nanda , Leung, Daniel H. , Ng, Vicky L. , Pai, Anita K., Pan, Debra H. , Shakhin, Victoria , Stoll, Janis , Wadera, Sheetal, Squires, James E. , (SPLIT), the Society of Pediatric Liver Transplantation, Lobritto, Steve , Elisofon, Scott A , Feldman, Amy , Gutierrez Sanchez, Luz Helena , Hildreth, Amber N , Himes, Ryan , Ibrahim, Samar H , Kerkar, Nanda , Leung, Daniel H , Mazareigos, George , Ng, Vicky L , Peters, Anna L , Shakhin, Victoria , Hsu, Evelyn , Squires, James E , Valentino, Pamela , Society of Pediatric Liver Transplantation (SPLIT) , Sanchez, Luz Helena Gutierrez , Hildreth, Amber , Jain, Ajay K. , Mazariegos, George , Valentino, Pamela L. , (SPLIT), the Society of Pediatric Liver Transplantation
Pediatric Transplantation | June 16, 2025 | Volume: 29 | Issue: 5 | Pages: No page available
ABSTRACT Background The Society of Pediatric Liver Transplantation (SPLIT) has undergone tremendous growth with > 45 sites contributing data focusing on improving outcomes in pediatric liver transplantation (LT). We report and compare outcomes from the SPLIT Registry. Methods Patients < 18 years with first‐time LT only enrolled into the SPLIT Registry between 2011 and 2023 were included. Data was stratified into eras from the last published registry update (era 1: 2011–2018, era 2: 2018–2023). Results Three thousand five hundred four participants from 47 centers were included (era 1: n = 2159; era 2: n = 1345). Age distribution differed with more children < 1 year. of age at LT in era 2 (era 1: 29% vs. era 2: 33%, p = 0.01). Indications for LT were similar, with biliary atresia (38.8%) and metabolic disease (16.0%) being most common. Exception point use was higher in era 2 (era 1: 45% vs. era 2: 56%, p < 0.001). No difference in graft type (deceased: 81% era 1 vs. 78% era 2, p = 0.78), patient survival at 90 days (era 1: 98.7% vs. era 2: 98.3%), 1 year (era 1: 97.2 vs. era 2: 96.8%), or 3 years (era 1: 95.3% vs. era 2: 95.2%) was noted. Rate of hepatic artery thrombosis was lower in era 2 (era 1: 7% vs. era 2: 5%, p = 0.02). Conclusions Trends in pediatric LT within SPLIT note similar LT indications and graft type, higher utilization of exception points, and lower HAT rates despite transplanting more children < 10 kg. This data underscores the evolution of pediatric LT toward higher survivability and overall patient outcomes.