Citations 3
Female Gender Remains an Independent Risk Factor for Poor Outcome after Acute Nontraumatic Intracerebral Hemorrhage
Ganti, Latha , Jain, Anunaya, Yerragondu, N., Jain, Minal , Bellolio, Fernanda , Gilmore, R.M. , Rabinstein, Alejandro A. , Bellolio, M Fernanda
Neurology Research International | September 5, 2013 | Volume: 2013 | Issue: No issue available | Pages: 1-7
The Triglyceride Paradox in Stroke Survivors: A Prospective Study
Jain, Minal , Jain, Anunaya, Yerragondu, N., Brown, Robert D. , Jahromi, Babak S. , Vaidyanathan, Lekshmi, Blyth, Brian, Ganti, Latha , Rabinstein, Alejandro A. , Jahromi, Babak S
Neuroscience Journal | February 25, 2013 | Volume: 2013 | Issue: No issue available | Pages: 1-7
Objective. The purpose of our study was to understand the association between serum triglycerides and outcomes in acute ischemic stroke (AIS) patients. Methods. A cohort of all adult patients presenting to the Emergency Department (ED) with an AIS from March 2004 to December 2005 were selected. The lipid profile levels were measured within 24 hours of stroke onset. Demographics, admission stroke severity (NIHSS), functional outcome at discharge (modified Rankin Scale (mRS)), and mortality at 3 months were recorded. Results. The final cohort consisted of 334 subjects. A lower level of triglycerides at presentation was found to be significantly associated with worse National Institutes of Health Stroke Scale (NIHSS) (P=0.004), worse mRS (P=0.02), and death at 3 months (P=0.0035). After adjusting for age and gender and NIHSS, the association between triglyceride and mortality at 3 months was not significant (P=0.26). Conclusion. Lower triglyceride levels seem to be associated with a worse prognosis in AIS.
Cardioembolic but Not Other Stroke Subtypes Predict Mortality Independent of Stroke Severity at Presentation
Ganti, Latha , Gilmore, R.M. , Bellolio, Fernanda , Jain, Anunaya, Decker, Wyatt W., Brown, Robert D. , Rabinstein, Alejandro A. , Agarwal, Dipti , Bellolio, M Fernanda
Stroke Research and Treatment | October 10, 2011 | Volume: 2011 | Issue: No issue available | Pages: 1-5
Introduction. Etiology of acute ischemic stroke (AIS) is known to significantly influence management, prognosis, and risk of recurrence.Objective. To determine if ischemic stroke subtype based on TOAST criteria influences mortality.Methods. We conducted an observational study of a consecutive cohort of patients presenting with AIS to a single tertiary academic center.Results. The study population consisted of 500 patients who resided in the local county or the surrounding nine-county area. No patients were lost to followup. Two hundred and sixty one (52.2%) were male, and the mean age at presentation was 73.7 years (standard deviation, SD = 14.3). Subtypes were as follows: large artery atherosclerosis 97 (19.4%), cardioembolic 144 (28.8%), small vessel disease 75 (15%), other causes 19 (3.8%), and unknown 165 (33%). One hundred and sixty patients died: 69 within the first 30 days, 27 within 31–90 days, 29 within 91–365 days, and 35 after 1 year. Low 90-, 180-, and 360-day survival was seen in cardioembolic strokes (67.1%, 65.5%, and 58.2%, resp.), followed for cryptogenic strokes (78.0%, 75.3%, and 71.1%). Interestingly, when looking into the cryptogenic category, those with insufficient information to assign a stroke subtype had the lowest survival estimate (57.7% at 90 days, 56.1% at 180 days, and 51.2% at 1 year).Conclusion. Cardioembolic ischemic stroke subtype determined by TOAST criteria predicts long-term mortality, even after adjusting for age and stroke severity.