Citations 1
Increasing Fluconazole Resistance in Candida parapsilosis : A 10-Year Analysis of Blood Culture Isolates at a US Reference Laboratory (2015–2024)
McHugh, Jack , Chesdachai, Supavit , Dunsirn, Murray, Wengenack, Nancy L. , Vergidis, Paschalis , Wengenack, Nancy, McHugh, Jack , Vergidis, Paschalis , Chesdachai, Supavit
The Journal of Infectious Diseases | May 12, 2025 | Volume: 232 | Issue: 5 | Pages: 1198-1202
Abstract Antifungal susceptibility testing among 1740 Candida parapsilosis blood isolates submitted to a United States reference laboratory (2015–2024) revealed a significant increase in fluconazole resistance from 8.2% to 20.3% (odds ratio [OR] per year, 1.13 [95% confidence interval {CI}, 1.06–1.20]; P < .001), with notable acceleration since 2021. Voriconazole resistance remained stable over this period. Micafungin resistance was rare, but intermediate susceptibility significantly increased, especially after 2021 (OR per year, 1.42 [95% CI, 1.25–1.63]; P < .001). These findings highlight important recent shifts in antifungal susceptibility among C parapsilosis isolates, emphasizing the need for ongoing surveillance and stewardship.