Idiopathic multicentric osteolysis (IMO) is a rare disease characterized by rapid spontaneous bone loss, typically affecting the carpal and tarsal bones. Patients with IMO often suffer from chronic pain, immobility, and renal disease, posing challenges for pain control in the perioperative setting. We present the case of a 19-year-old woman with Gorham-Stout syndrome, a subtype of IMO, who underwent a successful femoral nerve block and catheter placement under general anesthesia for palliative knee resection. This case report illustrates the safety and efficacy of regional anesthesia for postoperative pain control, emphasizing its potential benefits in this unique patient population.