Citations 1
Dimethyl fumarate attenuates bile acid retention and liver fibrosis in a mouse model of cholestasis
Laštůvková, Hana , Dohnálková, Ester , Manna, D., Pejchal, Jaroslav , Hirsova, Petra , Nachtigal, Petr , Bajnokova, Maria , Štefela, Alžběta , Kamaraj, Rajamanikkam , Jandová, Lenka , Uher, Martin , Manna, Dina Faeq , Pejchal, Jaroslav , Hirsova, Petra , Bajnokova, Maria , Smutna, Lucie , Stefela, Alzbeta , Kamaraj, Rajamanikkam , Jandova, Lenka , Pavek, Petr , Micuda, Stanislav , Hroch, Milos , Cermanová, Jolana , Mokrý, Jaroslav , Pávková, Ivona , Mičuda, Stanislav
American Journal of Physiology-Gastrointestinal and Liver Physiology | April 10, 2025 | Volume: 328 | Issue: 5 | Pages: G558-G577
Chronic cholestatic cholangiopathies present a therapeutic challenge due to their complex pathophysiology, where the accumulation of bile acids plays a crucial role. In this study, we found that dimethyl fumarate attenuated cholestatic liver damage in a murine model through its significant anti-inflammatory and antifibrotic activity supported by reduced bile acid accumulation in the plasma and liver via their increased fecal excretion.