Citations 2
Unveiling Misdiagnosis: Rethinking Seronegative NMOSD
Lang, Mary V. , Welk, Grant M., Tajfirouz, Deena , Chodnicki, Kevin D. , Pittock, Sean J., Chen, John J. , Tajfirouz, Deena , Flanagan, E P , Chen, John J , Welk, Grant M. , Lang, Mary , Pittock, Sean J., Flanagan, Eoin P.
Multiple Sclerosis Journal | August 16, 2025 | Volume: 31 | Issue: 11 | Pages: 1381-1384
Seronegative neuromyelitis optica spectrum disorder (NMOSD) is a diagnostic challenge. This study aimed to characterize misapplication of the 2015 international criteria for seronegative NMOSD. We reviewed 35 consecutive seronegative NMOSD referrals to a tertiary center. Two (6%) met formal criteria, and 2 (6%) were clinically suspected of NMOSD without fulfilling radiologic supportive criteria. Alternative diagnoses were common including multiple sclerosis (37%), optic neuritis (14%), functional neurologic disorder (11%), and other (38%). Immunosuppression with rituximab was used in 3 of 4 patients with functional neurologic disorder. Misapplication of the 2015 criteria is common, and alternative explanations in seronegative NMOSD patients should be strongly considered.
The Frequency of Optic Disc Hemorrhages and Other Retinal Findings on Fundoscopic Examination in Acute MOGAD Optic Neuritis (P11-8.005)
Welk, Grant M., Tajfirouz, Deena , Chodnicki, Kevin D. , Pittock, Sean J, Chen, John , Welk, Grant M. , Tisavipat, Nanthaya , Rattanathamsakul, Natthapon , Lang, Mary, Pittock, Sean J. , Flanagan, Eoin P.
Neurology | April 7, 2025 | Volume: 104 | Issue: 7_Supplement_1 | Pages: No page available