Citations 2
Frequency of Seroconversion in Aquaporin‐4 Antibody Testing: Insights From Real‐World Data
Ongphichetmetha, Tatchaporn , Du, Mengke , Vorasoot, Nisa , Pittock, Sean J. , Kunchok, Amy , Pittock, S J , Pittock, Sean J , Vorasoot, Nisa , Cohen, Jeffrey Allen
Annals of Clinical and Translational Neurology | September 17, 2025 | Volume: 12 | Issue: 10 | Pages: 2158-2163
ABSTRACTClinicians often repeat aquaporin‐4‐immunoglobulin G (AQP4‐IgG) testing in case of possible seroconversion. Compared with older, less sensitive immunofluorescence assays (IFA), cell‐based assays (CBA) offer higher sensitivity. This study assessed the frequency of seroconversion in a retrospective Cleveland Clinic cohort (2006–2024) of 451 patients with an initial negative AQP4‐IgG result who underwent serial testing. Seroconversion occurred in 4.3% (7/170) of patients initially tested by tissue IFA, but in none (0/263) of those tested by CBA. The lack of AQP4‐IgG seroconversion after a negative CBA, with only rare cases after a negative IFA, suggests that repeat AQP4‐IgG testing is low yield unless prior testing used older methods such as IFA.
Frequency of Seroconversion in Aquaporin-4 Antibody Testing: Insights from Real-World Data (P12-8.001)
Du, Mengke , Ongphichetmetha, Tatchaporn , Vorasoot, Nisa , Pittock, Sean J. , Cohen, Jeffrey Allen , Kunchok, Amy
Neurology | April 7, 2025 | Volume: 104 | Issue: 7_Supplement_1 | Pages: No page available