Vanegas, Natalia-Del Pilar
https://orcid.org/0000-0001-5135-1714
Mayo Clinic
The Ohio State University
Citations 2
Loss of lung mesenchymal identities in culture and a screening approach to identify restorative cues
Espinosa, Ana M. Diaz , Vanegas, Natalia-Del Pilar , Rodriguez-Lopez, Jhonny , Choi, Kyoung Moo , Schussler, Nichole A., Link, Patrick A. , Barringer, Grant, Rojas, Mauricio , Tschumperlin, Daniel J. , Diaz Espinosa, Ana M , Wellmerling, Jack H, Vanegas, Natalia Del Pilar , Rodriguez-Lopez, Jhonny , Choi, Kyoung M , Link, Patrick A , Rojas, Mauricio , Tschumperlin, Daniel J , Wellmerling, Jack , Schussler, Nichole A., Rodríguez, L. Raposo
American Journal of Physiology-Lung Cellular and Molecular Physiology | November 10, 2025 | Volume: 329 | Issue: 6 | Pages: L732-L748
Recent studies highlight transcriptionally distinct fibroblast subpopulations in human lungs. We observed the loss of these native transcriptional programs as fresh isolated cells are maintained in traditional culture conditions. Identifying the signals defining native fibroblast identities will be pivotal to creating culture models that preserve unique subpopulations. The screening system developed here will allow the investigation of a broad selection of cues, leading to better culture models for studying human lung fibroblast function and plasticity.
The Fourth Annual Symposium of the Midwest Aging Consortium
Kim, Jinoh , Buffenstein, Rochelle , Vanegas, Natalia-Del Pilar , Agudelo-Garcia, Paula A., Rojas, Mauricio , Englund, Davis A. , Nunes, Allancer , Kohut, Marian L. , Kothadiya, Siddhant , Bardhan, Rizia , Camell, Christina D. , Sturmlechner, Ines , Lamming, Dudley W. , Leiser, Scott F. , Escorcia, Wilber , Gill, Matthew S. , Helfand, Stephen L., Korm, Sovannarith , Pehar, Mariana , Blaszkiewicz, Magdalena , McGregor, Eric R. , Stilgenbauer, Lukas , Taylor, Alicia , McNeill, Elizabeth M. , Sturmlechner, Ines , Lamming, Dudley W , Anderson, Rozalyn M , Bai, Hua , Englund, Davis A. , Bronikowski, Anne M. , Rosas, Lorena , Mora, Ana Lucia , LeBrasseur, Nathan K. , Robbins, Paul D. , Goronzy, Jörg J. , Yeh, Chung‐Yang , Huang, Shijiao , Taylor, Jackson R. , Gribble, Kristin E. , Townsend, Kristy L. , Anderson, Rozalyn M. , Sadagurski, Marianna , Stoeger, Thomas
The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences | November 5, 2024 | Volume: 79 | Issue: 11 | Pages: No page available
Abstract The Midwest Aging Consortium (MAC) has emerged as a critical collaborative initiative aimed at advancing our understanding of aging and developing strategies to combat the rising prevalence of age-related diseases. Founded in 2019, MAC brings together researchers from various disciplines and institutions across the Midwestern United States to foster interdisciplinary geroscience research. This report summarizes the highlights of the Fourth Annual Symposium of MAC, which was held at Iowa State University in May 2023. The symposium featured presentations on a wide array of topics, including studies on slow-aging animals, cellular senescence and senotherapeutics, the role of the immune system in aging, metabolic changes in aging, neuronal health in aging, and biomarkers for measuring the aging process. Speakers shared findings from studies involving a variety of animals, ranging from commonly used species such as mice, rats, worms, yeast, and fruit flies, to less-common ones like naked mole-rats, painted turtles, and rotifers. MAC continues to emphasize the importance of supporting emerging researchers and fostering a collaborative environment, positioning itself as a leader in aging research. This symposium not only showcased the current state of aging biology research but also highlighted the consortium’s role in training the next generation of scientists dedicated to improving the healthspan and well-being of the aging population.