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Vilaça, Andreia

https://orcid.org/0000-0002-7063-280X

Mayo Clinic

Centro de Inovação em Biomedicina e Biotecnologia

Citations 1

Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence
Novo, João P. , Gee, Lucy, Caetano, Carolina A., Tomé, Inês , Vilaça, Andreia , Jurk, Diana , Rosa, Susana , Ferreira, Lino , Caetano, Carolina , Jurk, Diana , Ferreira, Lino , Zglinicki, Thomas von , Moreira, Irina Sousa

Aging Cell | August 15, 2024 | Volume: 23 | Issue: 9 | Pages: No page available

10.1111/acel.14270 Get It

AbstractBBB dysfunction during aging is characterized by an increase in its permeability and phenotypic alterations of brain endothelial cells (BECs) including dysregulation of tight junction's expression. Here we have investigated the role of BEC senescence in the dysfunction of the BBB. Our results suggest that the transition from young to aged BBB is mediated, at least in part by BEC senescence.