Joglekar, Mugdha M.
https://orcid.org/0000-0001-7945-7334
Mayo Clinic
University Medical Center Groningen
Citations 1
The lung extracellular matrix protein landscape in severe early-onset and moderate chronic obstructive pulmonary disease
Joglekar, Mugdha M. , Bekker, Nicolaas J. , Ngassie, Maunick Lefin Koloko , Vonk, Judith M. , Borghuis, Theo, Reinders-Luinge, Marjan, Bakker, Janna, Woldhuis, Roy R. , Pouwels, Simon D. , Timens, Wim , Brandsma, Corry‐Anke , Burgess, Janette K. , Koloko Ngassie, Maunick Lefin , Melgert, Barbro N , Timens, Wim , Brandsma, Corry-Anke , Burgess, Janette K , Vonk, Judith M
American Journal of Physiology-Lung Cellular and Molecular Physiology | June 25, 2024 | Volume: 327 | Issue: 3 | Pages: L304-L318
Our study identified chronic obstructive pulmonary disease (COPD)-associated differences in the lung extracellular matrix (ECM) composition. We highlight the compartmental differences in the ECM landscape in different subtypes of COPD. The most prominent differences were observed for severe-early onset COPD. Moreover, we identified unique ECM signatures that describe airway walls and parenchyma providing insight into the intertwined nature and complexity of ECM changes in COPD that together drive ECM remodeling and may contribute to disease pathogenesis.