Citations 2
Indocyanine green assists with sentinel lymph node mapping in pediatric and adolescent patients: A Pediatric Surgical Oncology Research Collaborative prospective observational study
Schermerhorn, Sophia M. V. , Vore, Emily , Bondoc, Alexander J, Ayala, Samantha, Kastenberg, Zachary J. , Arkin, Cameron, Malek, Marcus M. , Campwala, Insiyah, Aldrink, Jennifer H. , Horvath, Kyle , Piché, Nelson , Osman, Yasmin, Brown, Erin G, Doyle, Kathleen, Abril, Paige, Roach, Jonathan P, Ziogas, Ioannis A. , Rhee, Daniel S. , Chidiac, Charbel, Debertin, Julia , Craig, Brian T. , Lee, W. N., Barkhordar, Aaron, Joshi, Devashish , Stellon, Michael , Davies, Dafydd A., Boehmer, Chloé , Dasgupta, Roshni, Kastenberg, Zachary J , Arkin, Cameron , Malek, Marcus M , Aldrink, Jennifer H , Horvath, Kyle Z , Polites, Stephanie F. , Lee, William G , Barkhordar, Aaron , Joshi, Devashish , Beckhorn, Catherine , Dasgupta, Roshni , Bondoc, Alexander , Lautz, Timothy B. , Campwala, Insiyah , Brown, Erin G. , Roach, Jonathan P. , Chidiac, Charbel , Lal, Dave R. , Kim, Eugene S. , Le, Hau D. , Tracy, Elisabeth T. , Beckhorn, Catherine B , Dasgupta, Roshni
Cancer | February 7, 2026 | Volume: 132 | Issue: 4 | Pages: No page available
ABSTRACT Background Sentinel lymph node (SLN) biopsy is a critical staging tool in skin and soft tissue cancers. Although technetium lymphoscintigraphy is the most common adjunct, indocyanine green (ICG) demonstrates a promising alternative in pediatric, adolescent, and young adult (AYA) skin and soft tissue cancers. Methods and Objectives Evaluate the safety and efficacy of ICG in SLN biopsy (SLNB) in diverse pediatric and AYA solid cancers in a multi‐institutional environment. This is a prospective, observational study conducted at 13 member institutions in the Pediatric Surgical Oncology Research Collaborative between 2019 and 2023. Eligible patients underwent SLNB for primary or recurrent solid skin and soft tissue tumors. Peritumoral ICG was administered intraoperatively. Outcomes included SLN detection rates, histopathology of excised specimens, and surgeon‐reported assessment of utility. Safety was assessed through adverse event reporting. Results Forty SLNB procedures yielded 84 specimens: 13 melanoma (32.5%), 12 squamous cell carcinoma (30%), 11 non‐rhabdomyosarcoma soft tissue sarcoma (27.5%), two rhabdomyosarcoma (5%), one Ewing sarcoma (2.5%), and one malignant peripheral nerve sheath tumor (2.5%). Histologic evaluation identified 81 lymph nodes, 75 benign (89.3%) and six malignant (7.1%); three specimens were adipose tissue (3.6%). Of 81 lymph nodes, 76% were ICG‐positive. ICG had a sensitivity of 79.5%, a specificity of 33%, and a positive predictive value of 96%. All malignant nodes were ICG‐avid. There were no adverse reactions to ICG at 30 days. Conclusions ICG is a safe and effective adjunct for SLNB in pediatric and AYA soft tissue and skin malignancies.
Nutritional Profile, Disease Severity, and Quality of Life of Patients with Inflammatory Bowel Disease: A Case–Control Study
Sayegh, Lea N. , Haddad, Firas , Jaoude, Layane Bou , Fakhoury-Sayegh, Nicole , Heraoui, Gessica N. H. A., Nasrallah, Zainab , Chidiac, Charbel , Nawfal, Rashad , Francis, Fadi, Mourad, Fadi H. , Hashash, Jana G. , Hashash, Jana G , Sayegh, Lea Nicole , Mourad, Fadi H
Nutrients | June 11, 2024 | Volume: 16 | Issue: 12 | Pages: 1826
Introduction: Diet is thought to play an important role in the clinical course and quality of life (QOL) of patients with inflammatory bowel disease (IBD). However, dietary habits of patients with IBD are still unknown. This case–control study aims to compare the dietary habits of patients with IBD to healthy controls and evaluate differences in disease severity and QOL. Materials and methods: Food frequency, severity scores using the Harvey–Bradshaw and Ulcerative colitis activity index, and QOL were assessed using online questionnaires. Dietary habits were compared for patients with active disease and remission and for those with low QOL (LQOL) and high QOL (HQOL). Results: We recruited 61 patients with IBD and 101 controls. Significance was set at p = 0.05. Controls consumed significantly more daily calories (2546 vs. 1641, p = 0.001). However, patients with IBD consumed a higher percentage of carbohydrates (50% vs. 45%, p = 0.001), more red meat (p = 0.024), and less fiber, sucrose, and lactose (p = 0.001, 0.001, and 0.036). Patients with active disease had higher lipid intake, lower protein intake, and lower QOL (47 vs. 58, p = 0.001). Dietary differences between LQOL and HQOL mirrored those between active disease and remission. Conclusion: This study is the first to provide valuable insights into the nutritional profile of Lebanese patients with IBD.