Citations 1
Global epidemiology of early‐onset upper gastrointestinal cancer: trend from the Global Burden of Disease Study 2019
Danpanichkul, Pojsakorn , Auttapracha, Thanida , Kongarin, Siwanart , Jaruvattanadilok, Supitchaya , Saowapa, Sakditad , Suparan, Kanokphong , Liangpunsakul, Suthat , Wallace, Michael B. , Lui, Rashid , Wijarnpreecha, Karn , Wallace, Michael B , Danpanichkul, Pojsakorn , Ponvilawan, Ben , Simadibrata, Daniel Martin , Duangsonk, Kwanjit , Wijarnpreecha, Karn
Journal of Gastroenterology and Hepatology | May 22, 2024 | Volume: 39 | Issue: 9 | Pages: 1856-1868
AbstractBackground and AimIn recent years, there has been a growing incidence of gastrointestinal cancer in young individuals. Despite its significant morbidity and mortality, research on upper gastrointestinal (UGI) cancer in young populations has been relatively limited. Therefore, studies on the epidemiological changes of this cancer are needed.MethodsUsing data from the Global Burden of Disease Study 2019, we examined the incidence, death, and disability‐adjusted life years (DALYs) from UGI cancers in the young, namely, early‐onset esophageal cancer (EOEC) and early‐onset gastric cancer (EOGC). These results were stratified by sex, geographical region, country, and sociodemographic index.ResultsThere was a total of 185 140 cases, 120 289 deaths, and 5.70 million DALYs attributable to early‐onset UGI cancers globally. From 2010 to 2019, the global incidence, death, and DALYs rates of early‐onset UGI cancers decreased. In contrast, the incidence rates increased in both EOEC (+1.15%) and EOGC (+0.21%) in the Eastern Mediterranean region.ConclusionsOver the past decade, the burden of UGI cancer in the young has decreased. However, it has increased in the Eastern Mediterranean region. Further research to elucidate the attributable risk factors in this population is warranted.