Citations 3
Clinical and Radiological Outcomes in People with Aquaporin-4 Antibody Positive Neuromyelitis Optica Spectrum Disorder Following Ravulizumab Treatment (AMAZE) (P4-1.009)
Okuda, Darin, Burgess, Katy, McCreary, Morgan, Santoyo, Jose, Huddleston, Isabella, Tran, Diem, Moog, Tatum, Punnen, Tom, Patel, M, Fang, Yu , Pinho, Marco , Wright, Crystal, Hardeman, Paula, Blackburn, Kyle, Munoz, Shanan, Tardo, Lauren, Kantarci, O, Siva, Aksel, Frenay, Christine Lebrun, Sabatella, Guido, Stankowski, Jeannette, Fam, Sami , Sguigna, Peter, Okuda, Darin, Burgess, Katy W. , McCreary, Morgan , Santoyo, Jose R. , Huddleston, Isabella , Tran, Diem H., Moog, Tatum M. , Punnen, Tom G. , Patel, Madhukar S. , Pinho, Marco, Wright, Crystal , Hardeman, Paula, Greenberg, Benjamin , Blackburn, Kyle , Munoz, Shanan B. , Tardo, Lauren M. , Sıva, Aksel , Lebrun‐Frénay, Christine , Stankowski, Jeannette N. , Sguigna, Peter V.
Neurology | June 10, 2026 | Volume: 106 | Issue: 11_Supplement_1 | Pages: No page available
Low Incidence of Relapses After Vaccination in Anti‐Aquaporin‐4 Antibody‐Positive NMOSD
Pittock, Sean J. , Nakahara, Jin , Parks, Becky , Allen, Kerstin , Fam, Sami , Nakahara, Jin , Pittock, S J
Annals of Clinical and Translational Neurology | March 11, 2026 | Volume: 13 | Issue: 7 | Pages: 1488-1492
ABSTRACT Patients with neuromyelitis optica spectrum disorder (NMOSD) may experience increased signs and symptoms of their underlying disease when vaccinated against meningococcal disease before receiving complement component 5 inhibitor therapies. This retrospective analysis indicated an overall low relapse incidence (mean [range], 3.3% [0.7%–10.6%]) of physician‐reported relapses occurring within 4 weeks of meningococcal vaccination in those screened in CHAMPION‐NMOSD (NCT04201262), randomized to eculizumab or placebo in PREVENT (NCT01892345), and from the Japanese postmarketing surveillance of eculizumab in patients with anti‐aquaporin‐4 antibody‐positive NMOSD. Further studies are needed to determine if postvaccination relapses are attributable to vaccination or inherent relapse risk among these patients.
Indirect Treatment Comparison of Ravulizumab Versus Approved Treatment Options for Adults with Aquaporin-4 Immunoglobulin G-Positive (AQP4-IgG+) Neuromyelitis Optica Spectrum Disorder (NMOSD) (P10-14.005)
Clardy, Stacey , Aktaş, Orhan , Fam, Sami , Kielhorn, Adrian , Yu, Jeffrey , Jansen, Jeroen M. , Zhang, Ina, Clardy, Stacey L , Pittock, Sean J. , Nakahara, Jin , Isobe, Noriko , Centonze, Diego , Jansen, Jeroen
Neurology | April 9, 2024 | Volume: 102 | Issue: 7_supplement_1 | Pages: No page available