Citations 1
In vitro activity of sulbactam-durlobactam against colistin-resistant and/or cefiderocol-non-susceptible, carbapenem-resistant Acinetobacter baumannii collected in U.S. hospitals
Iovleva, Alina , McElheny, Christi L. , Fowler, Erin L., Cober, Eric , Herc, Erica , Arias, César A. , Hill, Carol , Baum, Keri, Fowler, Vance G. , Chambers, Henry F. , Greenwood‐Quaintance, Kerryl E. , Patel, Robin , van Duin, David , Bonomo, Robert A , Doi, Yohei , Hill, Carol , Arias, César A. , Fowler, Vance G. , Patel, Robin , Bonomo, Robert A. , Doi, Yohei
Antimicrobial Agents and Chemotherapy | January 30, 2024 | Volume: 68 | Issue: 3 | Pages: No page available
ABSTRACT The activity of a novel β-lactamase inhibitor combination, sulbactam-durlobactam (SUL-DUR), was tested against 87 colistin-resistant and/or cefiderocol-non-susceptible carbapenem-resistant Acinetobacter baumannii clinical isolates collected from U.S. hospitals between 2017 and 2019. Among them, 89% and 97% were susceptible to SUL-DUR and imipenem plus SUL-DUR, with MIC 50 /MIC 90 values of 2 µg/mL/8 µg/mL and 1 µg/mL/4 µg/mL, respectively. The presence of amino acid substitutions in penicillin-binding protein 3, including previously reported A515V or T526S, was associated with SUL-DUR non-susceptibility.