Friedrich, Oliver
https://orcid.org/0000-0003-2238-2049
Mayo Clinic
Friedrich-Alexander-Universität Erlangen-Nürnberg
Citations 1
Stretch response of the mechano-gated channel TMEM63A in membrane patches and single cells
Niloy, Sayeman Islam , Hannan, Elizabeth , Cowan, Luke M. , Linsenmeier, Fabian, Friedrich, Oliver , Farrugia, Gianrico , Beyder, Arthur , Strege, Peter R , Hannan, Elizabeth C, Cowan, Luke M , Farrugia, Gianrico , Beyder, Arthur , Strege, Peter R.
American Journal of Physiology-Cell Physiology | January 8, 2024 | Volume: 326 | Issue: 2 | Pages: C622-C631
TMEM63A has biophysical features distinctive for mechano-gated cation channels, but some properties are less clear, including no functional information in whole cells. We report that pressure-dependent yet voltage-independent TMEM63A currents in cell membrane patches correlated with cell size. In addition, radial stretch of whole cells on flexible membranes increased the [Ca2+]i responses more in TMEM63A-transfected cells. Inward TMEM63A currents in response to high stretch can depolarize plasma membranes and contribute to a sustained [Ca2+]i increase.