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Desai, Atharva

Mayo Clinic

University of Missouri–Kansas City

Citations 2

Patient Perceptions and Type 1 Delay in Head and Neck Cancer: A Scoping Review of High‐ and Low‐/Middle‐Income Countries
Anderson, Meredith A , Mayes, Connor, Desai, Atharva, Polen, Kyle , Black, Jeffrey L. , Reitz, Isabella, Taengwa, Gamaliel, Buhwa, Gordon, Chacon, Jose , BS, Anna Davide, Wiedermann, Joshua P. , Taengwa, Gamaliel , Davide, Anna , Anderson, Meredith Alexandra , Reitz, Isabella

Laryngoscope Investigative Otolaryngology | May 15, 2026 | Volume: 11 | Issue: 3 | Pages: No page available

10.1002/lio2.70427 Get It

ABSTRACT Objective To identify and compare how patient perceptions contribute to Type 1 Delays, defined as delays in deciding to seek care, among individuals with head and neck cancer (HNC) in high‐income countries (HICs) and low‐ and middle‐income countries (LMICs). Methods We conducted a scoping review and systematic search of MEDLINE, Embase, Cochrane Library, and Scopus from inception through November 20, 2023. Eligible studies included patients with HNC in HICs or LMICs who reported patient perceptions contributing to Type 1 Delays. Data extraction was performed in duplicate, and barriers were categorized thematically. Fisher's exact test was used to compare the frequency of reported barriers between HIC and LMIC studies. Results Seventeen studies met inclusion criteria, of which 64.7% ( n = 11) were conducted in HICs and 35.3% ( n = 6) in LMICs, representing 9 countries and 1410 participants. The most frequently cited perceptions contributing to delay were symptom unawareness, misinterpretation, and minimization. Additional barriers included fear of diagnosis, stigma, alternative medicine use, financial challenges, and geographic barriers. Transport/geographic barriers showed a trend toward being more common in LMIC studies ( p = 0.05). Descriptive patterns suggested LMIC patients more often reported structural and sociocultural barriers, whereas HIC patients more commonly cited psychosocial or perceptual barriers. Conclusion Type 1 Delays in HNC are common across both HICs and LMICs, with overlapping and region‐specific contributors. Tailored interventions, such as patient education, stigma reduction, and improved access to diagnostic services, may promote earlier detection and improve global HNC outcomes. Level of Evidence 3.
A Review of Anti-CD20 Antibodies in the Management of B-Cell Lymphomas
Mahadevia, Himil , Ananthamurugan, Mirdhula, Shah, Kashish, Desai, Atharva, Shrestha, Anuj

Lymphatics | January 5, 2024 | Volume: 2 | Issue: 1 | Pages: 10-24

10.3390/lymphatics2010002 Get It

Anti-CD20 monoclonal antibodies (mAbs) have revolutionized the treatment of lymphomas by improving the survival of patients, particularly in conjunction with chemotherapy. Until recently, the gold standard was based on the utilization of Rituximab (RTX) combined with chemotherapy. With our better understanding of monoclonal antibody (mAb) engineering, anti-CD20 mAb therapy has evolved to enhance clinical outcomes by improving pharmacokinetics, safety, activity and immunogenicity. Efforts to improve the on-targeting CD20 expressed on lymphomas through novel bioengineering techniques have led to the development of newer anti-CD20 mAbs that have accentuated complement-dependent cytotoxicity (CDC), antibody-dependent cell medicated cytotoxicity (ADCC), and/or a direct killing effect. There are several anti-CD20 monoclonal antibodies that have been evaluated for the treatment of lymphomas, some of which are now approved in addition to RTX.