Citations 1
Molecular mechanisms underlying TNFα-induced mitochondrial fragmentation in human airway smooth muscle cells
Dasgupta, Debanjali , Bhat, Sanjana Mahadev , Creighton, Claire, Cortes, Catherin, Delmotte, Philippe , Sieck, Gary C. , Mahadev Bhat, Sanjana , Sieck, Gary , Delmotte, Philippe , Dasgupta, Debanjali
American Journal of Physiology-Lung Cellular and Molecular Physiology | December 12, 2023 | Volume: 326 | Issue: 2 | Pages: L190-L205
Airway inflammation is increasing worldwide. Proinflammatory cytokines mediate an adaptive mechanism to overcome inflammation-induced cellular stress. Previously, we reported that TNFα mediates hASM cellular responses, leading to increased force and ATP consumption associated with increased O2 consumption, and oxidative stress. This study indicates that TNFα induces ER stress, which induces mitochondrial fragmentation via pIRE1αS724/XBP1s mediated CDK1/5 upregulation and pDRP1S616 phosphorylation. Mitochondrial fragmentation may promote hASM mitochondrial biogenesis to maintain healthy mitochondrial pool.