Citations 2
The Future Ain’t What It Used to Be…Out With the Old…In With the Better: Antibacterial Resistance Leadership Group Innovations
Patel, Robin , Hamasaki, Toshimitsu , Howard‐Anderson, Jessica , Kinamon, Tori, King, H. A. , Cross, H. R. , Chambers, Henry F. , Fowler, Vance G. , Boucher, Helen W., Group, for the Antibacterial Resistance Leadership, Schooley, Robert T. , Banerjee, Ritu , Souli, Maria , Sund, Zoë, Evans, Beth , Booth, Grant, Estes, Leslie, Greenwood‐Quaintance, Kerryl E. , Parmar, Krupa , Schwager, Nyssa, Wickward, Cathy, Geres, Holly, Dai, Weixiao , He, Yijie, Doernberg, Sarah B. , Satlin, Michael J. , Rouphael, Nadine , Baum, Keri, Raza, Praneeta , Komarow, Lauren , Hopkins, D. E., Zhang, Shanshan , Patel, Robin , Evans, Scott R , Evans, Scott , King, Heather A, Collyar, Deborah , Cross, Heather R, Fowler, Vance G. , Group, for the Antibacterial Resistance Leadership, Tamma, Pranita D. , Evans, Beth, Cunningham, Scott A. , Tillekeratne, L. Gayani , Dodd, Andrew, Hopkins, Deborah, Li, Yixuan , Tsalik, Ephraim L. , Holland, Thomas L
Clinical Infectious Diseases | October 16, 2023 | Volume: 77 | Issue: Supplement_4 | Pages: S321-S330
Abstract Clinical research networks conduct important studies that would not otherwise be performed by other entities. In the case of the Antibacterial Resistance Leadership Group (ARLG), such studies include diagnostic studies using master protocols, controlled phage intervention trials, and studies that evaluate treatment strategies or dynamic interventions, such as sequences of empiric and definitive therapies. However, the value of a clinical research network lies not only in the results from these important studies but in the creation of new approaches derived from collaborative thinking, carefully examining and defining the most important research questions for clinical practice, recognizing and addressing common but suboptimal approaches, and anticipating that the standard approaches of today may be insufficient for tomorrow. This results in the development and implementation of new methodologies and tools for the design, conduct, analyses, and reporting of research studies. These new methodologies directly impact the studies conducted within the network and have a broad and long-lasting impact on the field, enhancing the scientific value and efficiency of generations of research studies. This article describes innovations from the ARLG in diagnostic studies, observational studies, and clinical trials evaluating interventions for the prevention and treatment of antibiotic-resistant bacterial infections.
Priorities and Progress in Gram-negative Bacterial Infection Research by the Antibacterial Resistance Leadership Group
Satlin, Michael J. , Tyne, Daria Van , Rouphael, Nadine , Fowler, Vance G. , Hamasaki, Toshimitsu , Patel, Robin , Komarow, Lauren , Baum, Keri, Souli, Maria , Schwager, Nyssa, Doi, Yohei , Group, for the Antibacterial Resistance Leadership, Schooley, Robert T., Evans, Beth , Hopkins, D. E., Cathcart, F, Mocka, Elizabeth, Schuler, Carl, Sund, Zoë, Zaharoff, Smitha, Wickward, Cathy, Estes, Leslie, Mau, Donald, Booth, Grant, Abbenante, Erin, Bhojani, Minal, Zahir, Hirra, Ge, Lizhao , Giri, Abhigya, Dai, Weixiao , Diao, Guoqing , Fidler, Tamara, Shao, Wanying, Li, Yixuan , Zeng, Lijuan , Zhang, Shanshan , Greenwood‐Quaintance, Kerryl E. , Malan, Suzannah Schmidt, Parmar, Krupa , Ghazaryan, Varduhi , Raterman, Erica L., Samuel, Tamika, Lee, Marina S. , Doi, Yohei , Patel, Robin , Van Tyne, Daria , Evans, Scott R , van Duin, David , Tamma, Pranita D. , Lodise, Thomas P. , Rodvold, Keith A. , Evans, Scott , Fowler, Vance G. , Bonomo, Robert A. , Group, for the Antibacterial Resistance Leadership, Wang, Minggui, Wenzler, Eric , Evans, Beth, Hopkins, Deborah, Cathcart, Felecia, Schuler, Carl, Cunningham, Scott A. , Samuel, Tamika, Nayak, Seema
Clinical Infectious Diseases | October 16, 2023 | Volume: 77 | Issue: Supplement_4 | Pages: S305-S313
Abstract Addressing the treatment and prevention of antibacterial-resistant gram-negative bacterial infections is a priority area of the Antibacterial Resistance Leadership Group (ARLG). The ARLG has conducted a series of observational studies to define the clinical and molecular global epidemiology of carbapenem-resistant and ceftriaxone-resistant Enterobacterales, carbapenem-resistant Pseudomonas aeruginosa, and carbapenem-resistant Acinetobacter baumannii, with the goal of optimizing the design and execution of interventional studies. One ongoing ARLG study aims to better understand the impact of fluoroquinolone-resistant gram-negative gut bacteria in neutropenic patients, which threatens to undermine the effectiveness of fluoroquinolone prophylaxis in these vulnerable patients. The ARLG has conducted pharmacokinetic studies to inform the optimal dosing of antibiotics that are important in the treatment of drug-resistant gram-negative bacteria, including oral fosfomycin, intravenous minocycline, and a combination of intravenous ceftazidime-avibactam and aztreonam. In addition, randomized clinical trials have assessed the safety and efficacy of step-down oral fosfomycin for complicated urinary tract infections and single-dose intravenous phage therapy for adult patients with cystic fibrosis who are chronically colonized with P. aeruginosa in their respiratory tract. Thus, the focus of investigation in the ARLG has evolved from improving understanding of drug-resistant gram-negative bacterial infections to positively affecting clinical care for affected patients through a combination of interventional pharmacokinetic and clinical studies, a focus that will be maintained moving forward.