Citations 42
A mec A -Negative Strain of Methicillin-Resistant S taphylococcus aureus with Hig
Banerjee, Ritu , Gretes, Michael, Harlem, Christopher, Basuino, Li, Chambers, Henry F.
Antimicrobial Agents and Chemotherapy | August 30, 2010 | Volume: 54 | Issue: 11 | Pages: 4900-4902
ABSTRACT We previously generated a ceftobiprole-resistant S taphylococcus aureus strain after high inoculum serial passage of a mec A -negative variant of strain COL (R. Banerjee, M. Gretes, L. Basuino, N. Strynadka, and H. F. Chambers, Antimicrob. Agents Chemother. 52:2089-2096, 2008). Genome resequencing of this strain, CRB, revealed that it differs from its parent by five single-nucleotide polymorphisms in three genes, specifically, those encoding PBP4, a low-molecular-weight penicillin-binding protein, GdpP, a predicted signaling protein, and AcrB, a cation multidrug efflux transporter. CRB displayed resistance to a variety of β-lactams but was hypersusceptible to cefoxitin.
Rapid Drug Susceptibility Testing with a Molecular Beacon Assay Is Associated with Earlier Diagnosis and Treatment of Multidrug-Resistant Tuberculosis in California
Banerjee, Ritu , Allen, Jennifer R. , Lin, S.-Y. Grace, Westenhouse, Janice, Desmond, Ed, Schecter, Gisela, Scott, Cheryl, Raftery, Ann, Mase, Sundari , Watt, James, Flood, Jennifer
Journal of Clinical Microbiology | August 12, 2010 | Volume: 48 | Issue: 10 | Pages: 3779-3781
ABSTRACTTo assess the clinical impact of a molecular beacon (MB) assay that detects multidrug-resistant tuberculosis (MDR TB), we retrospectively reviewed records of 127 MDR TB patients with and without MB testing between 2004 and 2007. Use of the MB assay reduced the time to detection and treatment of MDR TB.