Waseta, Camille
Mayo Clinic
National Institute of Diabetes and Digestive and Kidney Diseases
Citations 1
Association between brain health outcomes and metabolic risk factors in persons with diabetes
Reynolds, Evan L. , Votruba, Kristen , Beare, Richard , Reid, Robert I. , Preboske, Gregory M., Waseta, Camille, Nelson, Robert G. , Callaghan, Brian C. , Reid, Robert I , Callaghan, Brian C , Feldman, Eva L , Jack, Clifford R. , Pop‐Busui, Rodica , Feldman, Eva L.
Annals of Clinical and Translational Neurology | July 31, 2023 | Volume: 10 | Issue: 10 | Pages: 1891-1898
AbstractWe performed a cross‐sectional study to determine associations between cognition and MRI‐derived brain outcomes, with obesity, diabetes duration, and metabolic risk factors in 51 Pima American Indians with longstanding type 2 diabetes (T2d) (mean [SD] age: 48.4 [11.3] years, T2d duration: 20.1 [9.1] years). Participants had similar cognition (NIH Toolbox Cognition Battery composite: 45.3 [9.8], p = 0.64, n = 51) compared to normative data. T2d duration, but not other metabolic risk factors, associated with decreased cortical thickness (Point Estimate (PE): −0.0061, 95%CI: −0.0113, −0.0009, n = 45), gray matter volume (PE: −830.39, 95%CI: −1503.14, −157.64, n = 45), and increased white matter hyperintensity volume (PE: 0.0389, 95%CI: 0.0049, 0.0729, n = 45).