Citations 2
Risankizumab Is Effective for The Management of Crohn’s Disease of the Pouch
Kayal, Maia , Spencer, Elizabeth A. , Smyth, Matthew D. , Raffals, Laura E. , Qazi, Taha , Deepak, Parakkal , Beniwal‐Patel, Poonam , Chang, Shannon, Higgins, Peter , Cross, Raymond, Anderson, Chelsea , Long, Millie D. , Dubinsky, Marla C. , Raffals, Laura , Dubinsky, Marla , Kayal, Maia , Deepak, Parakkal , Qazi, Taha , Herfarth, Hans , Barnes, Edward L.
Inflammatory Bowel Diseases | July 4, 2024 | Volume: 31 | Issue: 3 | Pages: 878-881
Lay Summary In this prospective, multicenter observational study of highly refractory patients with Crohn’s disease of the pouch, risankizumab achieved the primary outcome of clinical remission in 50% and the more stringent secondary outcome of antibiotic- and steroid-free remission in 30.8% at 12 weeks.
Dietary Patterns Are Not Associated With Disease Activity Among Patients With Inflammatory Conditions of the Pouch in a Prospective Cohort
Barnes, Edward L. , Beniwal‐Patel, Poonam , Deepak, Parakkal , Raffals, Laura H., Kayal, Maia , Dubinsky, Marla C. , Chang, Shannon, Higgins, Peter , Barr, Jennifer I, Anderson, Chelsea , Long, Millie D. , Herfarth, Hans , Herfarth, Hans H , Kayal, Maia , Deepak, Parakkal , Barnes, Edward L , Cross, Raymond K.
Crohn's & Colitis 360 | July 19, 2023 | Volume: 5 | Issue: 3 | Pages: No page available
Abstract Background Evidence-based recommendations regarding the influence of diet on inflammatory conditions of the pouch after restorative proctocolectomy with ileal pouch–anal anastomosis (IPAA) are limited. Methods We analyzed dietary patterns at enrollment in a prospective registry of patients with 1 of 4 inflammatory conditions of the pouch (acute pouchitis, chronic antibiotic-dependent pouchitis, chronic antibiotic refractory pouchitis, and Crohn’s disease of the pouch). We analyzed dietary intake by disease activity at enrollment and then compared dietary patterns among patients who remained in remission throughout the 12-month follow-up to those patients who experienced a disease relapse. We also compared dietary patterns among patients with inflammatory conditions of the pouch to the United States Department of Agriculture (USDA) recommended daily goals. Results Among 308 patients, there were no differences in dietary patterns among patients with 1 of the 4 disease states at enrollment. Additionally, among the 102 patients in remission at baseline, there were no significant differences noted among patients who went on to experience a disease flare in the 12 months after enrollment compared to those patients who remained in remission. However, patients with inflammatory conditions of the pouch demonstrated decreased intake of several food groups and macronutrients including dairy, fruits, vegetables, whole grains, and fiber when compared to USDA recommendations. Conclusions In a prospective cohort, we demonstrated no impact of dietary patterns on disease activity. The relative deficiencies in several food groups and macronutrients among patients after IPAA indicate the potential role of targeted nutritional counseling in this population.