Citations 1
HLA in isolated REM sleep behavior disorder and Lewy body dementia
Yu, Eric , Krohn, Lynne , Ruskey, Jennifer A. , Asayesh, Farnaz , Shah, Zalak , Hu, Michele T. M., Montplaisir, Jacques , Gagnon, Jean‐François , Désautels, Alex , Janes, Francesco , Bernardini, Andrea , Ibrahim, Abubaker , Heidbreder, Anna , Oertel, Wolfgang H. , Janzen, Annette , Figorilli, Michela , Puligheddu, Monica , Mollenhauer, Brit , Trenkwalder, Claudia , Sixel‐Döring, Friederike , Dijkstra, Femke, Viaene, Mineke , Abril, Beatriz, Scholz, Sonja W. , May, Patrick , Dauvilliers, Yves , Bernardini, Andrea , Stefani, Ambra , Janzen, Annette , Antelmi, Elena , Cochen De Cock, Valérie , Ferini-Strambi, Luigi , Rouleau, Guy Armand , Postuma, Ronald B , Scholz, Sonja W , Gan-Or, Ziv , May, Patrick , Ibrahim, Abubaker , Janes, Francesco , Figorilli, Michela , Puligheddu, Monica , Heidbreder, Anna , Spiegelman, Dan , Chia, Ruth , Arnulf, Isabelle , Hu, Michele T. M., Dauvilliers, Yves , Gigli, Gian Luigi , Valente, Mariarosaria , Högl, Birgit , Stefani, Ambra , Šonka, Karel , Dušek, Petr , Kemlink, David , Plazzi, Giuseppe , Antelmi, Elena , Boeve, Bradley F. , Postuma, Ronald B. , Gan‐Or, Ziv
Annals of Clinical and Translational Neurology | July 4, 2023 | Volume: 10 | Issue: 9 | Pages: 1682-1687
AbstractSynucleinopathies‐related disorders such as Lewy body dementia (LBD) and isolated/idiopathic REM sleep behavior disorder (iRBD) have been associated with neuroinflammation. In this study, we examined whether the human leukocyte antigen (HLA) locus plays a role in iRBD and LBD. In iRBD, HLA‐DRB1*11:01 was the only allele passing FDR correction (OR = 1.57, 95% CI = 1.27–1.93, p = 2.70e‐05). We also discovered associations between iRBD and HLA‐DRB1 70D (OR = 1.26, 95%CI = 1.12–1.41, p = 8.76e‐05), 70Q (OR = 0.81, 95%CI = 0.72–0.91, p = 3.65e‐04) and 71R (OR = 1.21, 95%CI = 1.08–1.35, p = 1.35e‐03). Position 71 (pomnibus = 0.00102) and 70 (pomnibus = 0.00125) were associated with iRBD. Our results suggest that the HLA locus may have different roles across synucleinopathies.