Citations 1
Immune niches in brain metastases contain TCF1+ stem-like T cells, are associated with disease control and are modulated by preoperative SRS
Jansen, Caroline S. , Chappa, Prasanthi, Zhou, Chengjing , Prokhnevska, Nataliya , Hoang, Kimberley B., Zhong, Jim , Torres, Mylin A. , Logan, Suzanna , Balzo, Luke del , Patel, Kirtesh R., Burri, Stuart H., Wilkinson, Scott , Lake, Ross , Patel, Pretesh, Dhere, Vishal R. , Sowalsky, Adam G. , Khan, Mohammad K. , Kissick, Haydn , Buchwald, Zachary S. , Wilkinson, Scott , Sowalsky, Adam G , Kissick, Haydn , Prabhu, Roshan S. , Pagadala, Meghana S. , Goyal, Subir , Neill, Stewart G. , Cardenas, Maria Andrea , Olson, Jeffrey J. , Nduom, Edjah Kweku-Ebura , Asher, Anthony L., Higgins, Kristin Ann
No container title available | March 22, 2023 | Volume: No volume available | Issue: No issue available | Pages: No page available
Abstract The CD8 + T-cell response is prognostic for survival outcomes in several tumor types. However, whether this extends to tumors in the brain, an organ with barriers to T cell entry, remains unclear. Here, we analyzed immune infiltration in 67 brain metastasis (BrM) and found high frequencies of PD1 + TCF1 + stem-like CD8 + T-cells and TCF1- effector-like cells. Importantly, the stem-like cells aggregate with antigen presenting cells in immune niches, and niches were prognostic for local disease control. Standard of care for BrM is resection followed by stereotactic radiosurgery (SRS), so to determine SRS’s impact on the BrM immune response, we examined 76 BrM treated with pre-operative SRS (pSRS). pSRS acutely reduced CD8 + T cells at 3 days. However, CD8 + T cells rebounded by day 6, driven by increased frequency of effector-like cells. This suggests that the immune response in BrM can be regenerated rapidly, likely by the local TCF1 + stem-like population.