Citations 1
COVID-19 in patients with neuroendocrine neoplasms: 2-year results of the INTENSIVE study
Fazio, Nicola , Gervaso, Lorenzo , Hálfdánarson, Þorvarður R. , Eiring, Rachel A. , Stocchetti, Benedetta Lombardi , Grozinsky‐Glasberg, Simona , Gross, David J. , Walter, Thomas , Robelin, Patrick, Bagnardi, Vincenzo , Antonuzzo, Lorenzo , Sparano, Clotilde , Gelsomino, Fabio, Rossi, Maura , Cives, Mauro , Kakil, I. R., Hamid, Hytam, Squadroni, M., Koumarianou, Anna, Boselli, S., Tamayo, Darina, Mazzon, Cristina, Rubino, Manila , Spada, Francesca , Sonbol, Mohamad, Grozinsky-Glasberg, Simona , Sparano, Clotilde , Massironi, Sara , Hofland, Johannes , Halfdanarson, Thorvardur R , Eiring, Rachel A , Antonuzzo, Lorenzo , Sonbol, Mohamad Bassam , Pusceddu, Sara , Prinzi, Natalie , Lombard‐Bohas, Catherine , Frassoni, Samuele , Gelsomino, Fabio , Bongiovanni, Alberto , Ranallo, Nicoletta , Tafuto, Salvatore , Chirco, Alessandra, Salvia, Anna La , Hernando, Jorge , Hofland, Johannes
Endocrine-Related Cancer | March 17, 2023 | Volume: 30 | Issue: 6 | Pages: No page available
We conducted a retrospective/prospective worldwide study on patients with neuroendocrine neoplasms (NENs) and a molecularly proven SARS-CoV-2 positivity. Preliminary results regarding 85 patients of the INTENSIVE study have been published in 2021. Now we are reporting the 2-year analysis.Here, we are reporting data from consecutive patients enrolled between 1 June 2020, and 31 May 2022. Among the 118 contacted centers, 25 were active to enroll and 19 actively recruiting at the time of data cut-off for a total of 280 patients enrolled. SARS-CoV-2 positivity occurred in 47.5% of patients in 2020, 35.1% in 2021, and 17.4% in 2022. The median age for COVID-19 diagnosis was 60 years. Well-differentiated tumors, non-functioning, metastatic stage, and gastroenteropancreatic (GEP) primary sites represented most of the NENs. COVID-19-related pneumonia occurred in 22.8% of the total, with 61.3% of them requiring hospitalization; 11 patients (3.9%) needed sub-intensive or intensive care unit therapies and 14 patients died (5%), in 11 cases (3.9%) directly related to COVID-19. Diabetes mellitus and age at COVID-19 diagnosis > 70 years were significantly associated with COVID-19 mortality, whereas thoracic primary site with COVID-19 morbidity. A significant decrease in both hospitalization and pneumonia occurred in 2022 vs 2020. In our largest series of NEN patients with COVID-19, the NEN population is similar to the general population of patients with NEN regardless of COVID-19. However, older age, non-GEP primary sites and diabetes mellitus should be carefully considered for increased COVID-19 morbidity and mortality. Relevant information could be derived by integrating our results with NENs patients included in other cancer patients with COVID-19 registries.