Citations 2
Human Leukocyte Antigen Class I and II Alleles and Overall Survival in Diffuse Large B-Cell Lymphoma and Follicular Lymphoma
Lu, Yani , Abdou, Amr M. , Cerhan, James R. , Morton, Lindsay M. , Severson, Richard K., Rothman, Nathaniel , Hartge, Patricia, Wang, Sophia , Davis, Scott , Cozen, Wendy , Bernstein, Leslie , Chanock, Stephen Jacob , Cerhan, James R , Morton, Lindsay M , Wang, Sophia S
The Scientific World JOURNAL | November 1, 2011 | Volume: 11 | Issue: No issue available | Pages: 2062-2070
Genetic variation in the 6p21 chromosomal region, including human leukocyte antigen (HLA) genes and tumor necrosis factor (TNF), has been linked to both etiology and clinical outcomes of lymphomas. We estimated the effects ofHLAclass I (A, B, and C), class IIDRB1alleles, and the ancestral haplotype (AH) 8.1 (HLAA*01-B*08-DRB1*03-TNF-308A) on overall survival (OS) among patients with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL) in a population-based study of non-Hodgkin lymphoma. During a median followup of 89 months, 31% (52 of 166) DLBCL and 28% (46 of 165) FL patients died. Using multivariate Cox regression models, we observed statistically significant associations between genetic variants and survival:HLA-Cw*07:01was associated with poorer OS among DLBCL patients (Hazard ratio [HR] = 1.76, 95% confidence interval [CI] = 1.01–3.05);HLA-A*01:01was associated with poorer OS (HR = 2.23, 95% CI = 1.24–4.01), andHLA-DRB1*13(HR = 0.12, 95% CI = 0.02–0.90) andHLA-B Bw4(HR = 0.36, 95% CI = 0.20–0.63) with better OS among FL patients. These results support a role forHLAin the prognosis of DLBCL and FL and represent a promising class of prognostic factors that warrants further evaluation.
Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology
Wang, Sophia , Abdou, Amr M. , Morton, Lindsay M. , Thomas, Rasmi , Cerhan, James R. , Gao, Xiaojiang, Rothman, Nathaniel , Severson, Richard K., Hartge, Patricia, Carrington, Mary , Cozen, Wendy , Davis, Scott , Bernstein, Leslie , Cerhan, James R , Morton, Lindsay M , Wang, Sophia S
Blood | April 13, 2010 | Volume: 115 | Issue: 23 | Pages: 4820-4823
AbstractGenome-wide association and candidate gene studies implicate different genetic variants within the 6p21 chromosomal region with different non-Hodgkin lymphoma (NHL) subtypes. Complementing these efforts, we conducted human leukocyte antigen (HLA) class I and class II genotyping among 610 NHL cases and 555 controls of non-Hispanic white descent from a US multicenter study. Allele-disease associations were assessed by logistic regression for NHL and its subtypes. Statistically significant associations between HLA and NHL subtypes include HLA-DRB1*0101 for follicular lymphoma (odds ratio [OR] = 2.14, P < .001), HLA-DRB1*0401 for diffuse large B-cell lymphoma (DLBCL; OR = 0.45, P = .006), and HLA-DRB1*13 and follicular lymphoma (OR = 0.48, P = .008). We further observed significant heterozygote advantage for HLA class I alleles and NHL, and particularly DLBCL (P trend = .01 for elevated risk with increasing number of homozygous alleles). Our results support a role for HLA in the etiology of NHL and its subtypes.