Shetty, Rajesh

Background and Objective: Optical coherence tomography (OCT) was used to evaluate the macular thickness in eyes with advanced glaucoma compared with eyes following a retinal artery occlusion. Patients and Methods: Ten patients with a retinal artery occlusion and 10 patients with severe glaucoma were evaluated with OCT using the macular thickness map protocol. Results: The median thinnest macular sector was 183 microns (range: 152 to 223 microns) in patients with glaucoma versus 143 microns (range: 98 to 177 microns) in patients with arterial occlusion ( P = .001). Median macular volume was 5.9 mm 3 (range: 5.1 to 6.7 mm 3 ) in patients with glaucoma versus 5.1 mm 3 (range: 3.6 to 6.1 mm 3 ) in patients with arterial occlusion ( P = .015). Conclusions OCT demonstrates that patients with a retinal artery occlusion have significantly reduced macular thickness compared with those with severe glaucoma. [Ophthalmic Surg Lasers Imaging 2007;38:392–398.]

Purpose. To compare the measurement of diurnal fluctuations in intraocular pressure (IOP) in the same day versus over different days in primary open-angle glaucoma. Methods. Twenty-five eyes from 25 patients with primary open-angle glaucoma were submitted to a diurnal curve on the same day, 5 measurements, 2.5 hours apart, from 8:00 AM to 6:00 PM. For the measurements on different days, we randomly selected one time point from the diurnal curve for each patient. All patients were then instructed to return every 3–7 days to complete all 5 measurements. The maximum, minimum, and IOP fluctuation were compared between the 2 methods. Results. The IOP fluctuation (maximum-minimum) was similar when we measured the IOP on different days (5.0±2.6 mmHg vs 4.0±1.2 mmHg, p=0.08). There was no difference regarding the minimum or maximum IOP assessed in the diurnal curve or over different days. There was a high correlation for the maximum IOP (r=0.863, p<0.001) and the minimum IOP (r=0.708, p<0.001) by either method of measuring during the same day or different days, as well as for all measurements (8:00 AM: r=0.718, p<0.001; 10:30 AM: r=0.479, p=0.01; 1:00 PM: r=0.628, p=0.001; 3:30 PM: r=0.757, p<0.001; and 6:00 PM: r=0.910, p<0.001). Conclusions. IOP fluctuation in primary open-angle glaucoma can be assessed using IOP measures on different days, at different time points, which strongly correlate to a diurnal curve.