Citations 2
Staphylococcus aureus proteases trigger eosinophil-mediated skin inflammation
Kline, Sabrina N. , Orlando, Nicholas , Lee, Alex J. , Wu, Meng-Chen , Zhang, Jing , Youn, Christine , Feller, Laine , Pontaza, Cristina , Dikeman, Dustin , Limjunyawong, Nathachit , Williams, Kaitlin L. , Wang, Yu , Jacobsen, Elizabeth A. , Dong, Xinzhong , Archer, Nathan K. , Orlando, Nicholas A , Wu, Meng-Jen , Feller, Laine E , Jacobsen, Elizabeth A , Garza, Luis A , Archer, Nathan K , Nolan, Sabrina J. , Čiháková, Daniela , Durum, Scott Kenneth
Proceedings of the National Academy of Sciences | January 30, 2024 | Volume: 121 | Issue: 6 | Pages: No page available
Staphylococcus aureus skin colonization and eosinophil infiltration are associated with many inflammatory skin disorders, including atopic dermatitis, bullous pemphigoid, Netherton’s syndrome, and prurigo nodularis. However, whether there is a relationship between S. aureus and eosinophils and how this interaction influences skin inflammation is largely undefined. We show in a preclinical mouse model that S. aureus epicutaneous exposure induced eosinophil-recruiting chemokines and eosinophil infiltration into the skin. Remarkably, we found that eosinophils had a comparable contribution to the skin inflammation as T cells, in a manner dependent on eosinophil-derived IL-17A and IL-17F production. Importantly, IL-36R signaling induced CCL7-mediated eosinophil recruitment to the inflamed skin. Last, S. aureus proteases induced IL-36α expression in keratinocytes, which promoted infiltration of IL-17-producing eosinophils. Collectively, we uncovered a mechanism for S. aureus proteases to trigger eosinophil-mediated skin inflammation, which has implications in the pathogenesis of inflammatory skin diseases.
Meeting the Challenges of Myocarditis: New Opportunities for Prevention, Detection, and Intervention—A Report from the 2021 National Heart, Lung, and Blood Institute Workshop
Čiháková, Daniela , Adhikari, Bishow B., Bandettini, W. Patricia , Cunningham, Madeleine W. , Danthi, Narasimhan , Longacre, Lisa Schwartz, Mann, Douglas L. , Tang, W.H. Wilson , Zhou, Guofei , Cooper, Leslie T. , Mann, Douglas L , Tang, W H Wilson , Cooper, Leslie T , Shi, Yang , Friedrich, Matthias G. , Liu, Peter Xiaoping , Świrski, Filip K.
Journal of Clinical Medicine | September 28, 2022 | Volume: 11 | Issue: 19 | Pages: 5721
The National Heart, Lung, and Blood Institute (NHLBI) convened a workshop of international experts to discuss new research opportunities for the prevention, detection, and intervention of myocarditis in May 2021. These experts reviewed the current state of science and identified key gaps and opportunities in basic, diagnostic, translational, and therapeutic frontiers to guide future research in myocarditis. In addition to addressing community-acquired myocarditis, the workshop also focused on emerging causes of myocarditis including immune checkpoint inhibitors and SARS-CoV-2 related myocardial injuries and considered the use of systems biology and artificial intelligence methodologies to define workflows to identify novel mechanisms of disease and new therapeutic targets. A new priority is the investigation of the relationship between social determinants of health (SDoH), including race and economic status, and inflammatory response and outcomes in myocarditis. The result is a proposal for the reclassification of myocarditis that integrates the latest knowledge of immunological pathogenesis to refine estimates of prognosis and target pathway-specific treatments.