Citations 2
Changes in Therapy Are Not Associated With Increased Remission in Patients With Crohn's Disease of the Pouch
Deepak, Parakkal , Beniwal‐Patel, Poonam , Raffals, Laura E. , Dubinsky, Marla C. , Higgins, Peter , Jiang, Yue , Cross, Raymond K. , Long, Millie D. , Deepak, Parakkal , Dubinsky, Marla , Chang, Shannon , Jiang, Yue , Cross, Raymond , Barnes, Edward L , Kayal, Maia , Chang, Sam S. , Herfarth, Hans , Barnes, Edward L.
American Journal of Gastroenterology | November 17, 2023 | Volume: 119 | Issue: 3 | Pages: 584-587
INTRODUCTION: There is a paucity of data on the real-world effectiveness of therapies in patients with Crohn's disease of the pouch. METHODS: This was a prospective multicenter study evaluating the primary outcome of remission at 12 months of therapy for Crohn's disease of the pouch. RESULTS: One hundred thirty-four patients were enrolled. Among the 77 patients with symptoms at baseline, 35 (46.7%) achieved remission at 12 months. Of them, 12 (34.3%) changed therapy. There was no significant association between therapy patterns and remission status. DISCUSSION: Approximately 50% with symptoms at enrollment achieved clinical remission at 12 months, most of whom did so without a change in therapy.
Treatment Patterns and Standardized Outcome Assessments Among Patients With Inflammatory Conditions of the Pouch in a Prospective Multicenter Registry
Barnes, Edward L. , Deepak, Parakkal , Beniwal‐Patel, Poonam , Raffals, Laura H., Kayal, Maia , Dubinsky, Marla C. , Chang, Shannon, Higgins, Peter , Barr, Jennifer I, Galanko, Joseph A. , Jiang, Yue , Long, Millie D. , Dubinsky, Marla , Herfarth, Hans H , Kayal, Maia , Deepak, Parakkal , Jiang, Yue , Barnes, Edward L , Chang, Shannon, Cross, Raymond K. , Herfarth, Hans
Crohn's & Colitis 360 | August 2, 2022 | Volume: 4 | Issue: 3 | Pages: No page available
Abstract Background Much of our understanding about the natural history of pouch-related disorders has been generated from selected populations. We designed a geographically diverse, prospective registry to study the disease course among patients with 1 of 4 inflammatory conditions of the pouch. The primary objectives in this study were to demonstrate the feasibility of a prospective pouch registry and to evaluate the predominant treatment patterns for pouch-related disorders. Methods We used standardized diagnostic criteria to prospectively enroll patients with acute pouchitis, chronic antibiotic-dependent pouchitis (CADP), chronic antibiotic refractory pouchitis (CARP), or Crohn’s disease (CD) of the pouch. We obtained detailed clinical and demographic data at the time of enrollment, along with patient-reported outcome (PRO) measures. Results We enrolled 318 patients (10% acute pouchitis, 27% CADP, 12% CARP, and 51% CD of the pouch). Among all patients, 55% were on a biologic or small molecule therapy. Patients with CD of the pouch were more likely to use several classes of therapy (P < .001). Among patients with active disease at the time of enrollment, 23% with CARP and 40% with CD of the pouch were in clinical remission at 6 months after enrollment. Conclusions In a population where most patients had refractory inflammatory conditions of the pouch, we established a framework to evaluate PROs and clinical effectiveness. This infrastructure will be valuable for long-term studies of real-world effectiveness for pouch-related disorders.