Citations 1
Circulating insulin-like growth factor system adaptations in hibernating brown bears indicate increased tissue IGF availability
Frøbert, Anne Mette , Brohus, Malene , Roesen, Tinna S., Kindberg, Jonas , Fröbert, Ole , Conover, Cheryl A. , Overgaard, Michael T.
American Journal of Physiology-Endocrinology and Metabolism | July 13, 2022 | Volume: 323 | Issue: 3 | Pages: E307-E318
Brown bears shift from circulating ternary IGF/IGFBP/ALS complexes in the active state to binary IGF/IGFBP complexes during hibernation, indicating increased tissue IGF-bioactivity. Furthermore, brown bears use a splice variant of IGF-2, suggesting increased bone-specific targeting of IGF anabolic signaling.