Citations 1
The effect of tissue culture on suture holding strength and degradation in canine tendon
Omae, Hiromichi, Zhao, Cathy , Zobitz, M. E., Moran, Steven L. , Amadio, Peter C. , Sun, Yu Long
Journal of Hand Surgery (European Volume) | July 8, 2009 | Volume: 34 | Issue: 5 | Pages: 643-650
The purpose of this study was to assess tendon metabolism and suture pull-out strength after simple tendon suture in a tissue culture model. One hundred and twelve flexor digitorum profundus tendons from 28 dogs were cultured for 7, 14, or 21 days with or without a static tensile load. In both groups increased levels of matrix metalloproteinase (MMP) mRNA was noted. Suture pull-out strength did not decrease during tissue culture. While the presence of a static load had no effect on the pull-out strength, it did affect MMP mRNA expression. This tissue culture model could be useful in studying the effect of factors on the tendon-suture interface.