Citations 2
TNFα-mediated subcellular heterogeneity of succinate dehydrogenase activity in human airway smooth muscle cells
Bhat, Sanjana Mahadev , Creighton, Claire C., Sieck, Gary C. , Mahadev Bhat, Sanjana , Creighton, Claire Catherine, Sieck, Gary , Creighton, Claire
American Journal of Physiology-Lung Cellular and Molecular Physiology | April 23, 2025 | Volume: 328 | Issue: 6 | Pages: L792-L808
Mitochondria show context-specific heterogeneity in their morphometry. Previously, we reported that acute TNFα exposure increased O 2 consumption rate (OCR) and mitochondrial volume density, but decreased OCR per mitochondrion. TNFα also altered mitochondrial distribution and motility. To assess TNFα-mediated subcellular mitochondrial structural and functional heterogeneity, we used a confocal-based quantitative histochemical technique to determine the maximum velocity of succinate dehydrogenase reaction. Our findings highlight that mitochondria within cells exhibit functional heterogeneity, which is disrupted during inflammation.
IRE1A/ XBP1s Axis of ER Stress Promotes DRP1 Phosphorylation at Specific Serine Residue (S616) and Induces Mitochondrial Fragmentation During Airway Inflammation
Delmotte, Philippe , Han, Yingdong , Creighton, Claire C., Botero, C. Cortes, Dasgupta, Debanjali , Bhat, Sanjana Mahadev , Han, Y.S., Creighton, Claire, Sieck, Gary C.
D109. AIRWAY OF INTEREST: EPITHELIAL AND SMOOTH MUSCLE FUNCTION IN HEALTH AND DISEASE | May 2, 2022 | Volume: No volume available | Issue: No issue available | Pages: A5484-A5484