Citations 2
Fact or Myth? Black Patients Do Not Want to Participate in Clinical Trials
Mills, Krystal , Knight, RaKetra, Ekpo, Emem T., Lee, Lilian C. , Baldo, Lance , Xu, Chuanbo , Wang, Siqi , Adelman, Robert M. , Pemu, Priscilla, Levin, Theodore R. , Liu, Julia J. , Liu, Julia J , Figueroa, Francisco, Knight, RaKetra, Shaukat, Aasma
Clinical and Translational Gastroenterology | January 29, 2025 | Volume: 16 | Issue: 4 | Pages: e00826
INTRODUCTION: To assess strategies for optimizing participation of underserved minorities in a blood-based early colorectal cancer detection test study (PREEMPT CRC; NCT04369053) at a hospital serving primarily Black individuals. METHODS: Culturally sensitive, racially congruent research staff approached individuals undergoing average-risk screening colonoscopy. Consent/study procedures were synchronized with clinical appointments. Enrolled and not-enrolled patient characteristics were compared. Recruitment was compared with other study sites. RESULTS: In total, 247 of 509 eligible individuals were enrolled; most were identified as Black (88.7%). No baseline characteristics were associated with participation. Recruitment was high compared with other sites (11th centile). DISCUSSION: Recruitment barriers for Black individuals can be overcome when easy, culturally sensitive access is facilitated.
Understanding T cell responses to COVID-19 is essential for informing public health strategies
Baldo, Lance , Morice, William G. , Wherry, E. John , Vardhana, Santosha , Baldo, Lance , Morice, William George , Wherry, E John
Science Immunology | March 24, 2022 | Volume: 7 | Issue: 71 | Pages: No page available
Durable T cell responses to SARS-CoV-2 antigens after infection or vaccination improve immune-mediated viral clearance. To date, population-based surveys of COVID-19 adaptive immunity have focused on testing for IgG antibodies that bind spike protein and/or neutralize the virus. Deployment of existing methods for measuring T cell immunity could provide a more complete profile of immune status, informing public health policies and interventions.