Citations 2
Comparison of the Respiratory Resistomes and Microbiota in Children Receiving Short versus Standard Course Treatment for Community-Acquired Pneumonia
Pettigrew, Melinda M. , Kwon, Jiye , Gent, Janneane F., Kong, Yong , Wade, Martina , Creech, C. Buddy , Pan, Qing , Walter, Emmanuel B. , Martin, Judith M. , Gerber, Jeffrey S. , Newland, Jason G. , Hofto, Meghan E. , Staat, Mary Allen , Fowler, Vance G. , Chambers, Henry F. , Pettigrew, M M , Martin, J M , Staat, Mary A , Williams, Derek J. , Evans, Scott , Fowler, Vance G. , Huskins, W. Charles
mBio | March 24, 2022 | Volume: 13 | Issue: 2 | Pages: No page available
Antibiotic resistance is a major threat to public health. Treatment strategies involving shorter antibiotic courses have been proposed as a strategy to lower the potential for antibiotic resistance.
Gastrointestinal Microbiome Disruption and Antibiotic-Associated Diarrhea in Children Receiving Antibiotic Therapy for Community-Acquired Pneumonia
Kong, Yong , Wade, Martina , Williams, Derek J. , Creech, C. Buddy , Walter, Emmanuel B. , Martin, Judy M, Gerber, Jeffrey S. , Newland, Jason G. , Hofto, Meghan E. , Staat, Mary Allen , Chambers, Henry F. , Fowler, Vance G. , Pettigrew, Melinda M. , Pettigrew, M M , Evans, Scott R , Staat, Mary A , Kwon, Jiye , Evans, Scott , Fowler, Vance G. , Huskins, W. Charles
The Journal of Infectious Diseases | March 2, 2022 | Volume: 226 | Issue: 6 | Pages: 1109-1119
Abstract Antibiotic-associated diarrhea (AAD) is a common side effect of antibiotics. We examined the gastrointestinal microbiota in children treated with β-lactams for community-acquired pneumonia. Data were from 66 children (n = 198 samples), aged 6–71 months, enrolled in the SCOUT-CAP trial (NCT02891915). AAD was defined as ≥1 day of diarrhea. Stool samples were collected on study days 1, 6–10, and 19–25. Samples were analyzed using 16S ribosomal RNA gene sequencing to identify associations between patient characteristics, microbiota characteristics, and AAD (yes/no). Nineteen (29%) children developed AAD. Microbiota compositional profiles differed between AAD groups (permutational multivariate analysis of variance, P < .03) and across visits (P < .001). Children with higher baseline relative abundances of 2 Bacteroides species were less likely to experience AAD. Higher baseline abundance of Lachnospiraceae and amino acid biosynthesis pathways were associated with AAD. Children in the AAD group experienced prolonged dysbiosis (P < .05). Specific gastrointestinal microbiota profiles are associated with AAD in children.