Citations 2
Association of Persistent Rubella Virus With Idiopathic Skin Granulomas in Clinically Immunocompetent Adults
Chen, Min‐hsin , Hao, Lijuan , Abernathy, Emily, Bender, Nicole R. , Shields, Bridget E. , Wilson, Barbara, Crosby, David L. , Routes, John M. , Samimi, Sara , Haun, Paul , Icenogle, Joseph P. , Sullivan, Kathleen E. , Rosenbach, Misha , Drolet, Beth A. , Sokumbi, Olayemi , Wanat, Karolyn A. , Perelygina, Ludmila
JAMA Dermatology | March 26, 2022 | Volume: 158 | Issue: 6 | Pages: 626
Multicancer early detection test: Preclinical, translational, and clinical evidence–generation plan and provocative questions
Kisiel, John B. , Papadopoulos, Nickolas , Liu, Minetta C. , Crosby, David L. , Srivastava, Sudhir , Hawk, Ernest T. , Kisiel, John B
Cancer | February 8, 2022 | Volume: 128 | Issue: S4 | Pages: 861-874
Minimally invasive molecular biomarkers have been applied to the early detection of multiple cancers in large scale case‐control and cohort studies. These demonstrations of feasibility herald the potential for permanent transformation of current cancer screening paradigms. This commentary discusses the major opportunities and challenges facing the preclinical development and clinical validation of multicancer early detection test strategies. From a diverse set of early detection research perspectives, the authors recommend specific approaches and highlight important questions for future investigation.