Citations 2
Management of obesity in liver transplant candidates and recipients: Rethinking the false dichotomy between pharmacotherapy and surgical intervention
Davis, Jessica P.E. , Reticker, Anesia , Han, Hyosun , Henry, Zachary , Schulman, Allison R. , Tincopa, Monica A. , Group, the AST LICOP Controversies Conference Working, Tincopa, Monica , Orandi, Babak John , Tsunoda, Shirley M. , Heimbach, Julie K. , Group, the AST LICOP Controversies Conference Working
Liver Transplantation | June 2, 2025 | Volume: 31 | Issue: 10 | Pages: 1286-1297
The prevalence of comorbid metabolic dysfunction–associated steatotic liver disease (MASLD) and obesity has increased exponentially over the last several years, with current estimates demonstrating that up to 40% of adults in the United States have MASLD. Metabolic dysfunction–associated steatohepatitis is now a leading indication for liver transplantation, and rates of obesity and MASLD pre-transplant and post-transplant are on the rise. Our understanding of the physiology of obesity and metabolic disease and the availability of effective obesity treatments have evolved over the same time frame. With the availability of new anti-obesity medications, there has been a debate over the role of pharmacotherapy versus interventional approaches in the treatment of obesity and MASLD in the liver transplantation population. In October 2024, the American Society of Transplantation (AST) Liver and Intestinal Community of Practice held a virtual Controversies Conference on obesity and liver transplantation. Experts in the field presented the available data, and smaller working groups had interactive breakout sessions that identified knowledge gaps and developed recommendations. This perspective prepared on behalf of the participants of the AST Controversies Conference on obesity and liver transplant aims to summarize the available evidence for surgical and pharmaceutical treatment in the liver transplantation population.
The use of nondirected donor organs in living donor liver transplantation: Perspectives and guidance
Fox, Alyson N. , Liapakis, AnnMarie , Batra, Ramesh , Bittermann, Therese , Emamaullee, Juliet , Emre, Sukru , Genyk, Yuri , Han, Hyosun , Jackson, Whitney E. , Rodríguez-Dávalos, Manuel I. , Gold, Susan Rubman, Shenoy, Akhil , Taner, Timuçin , (NALLDIG), The North American Living Liver Donor Innovations Group, Taner, Timucin , Pomfret, Elizabeth , Raza, Muhammad, Samstein, Benjamin , Roberts, John P. , (NALLDIG), The North American Living Liver Donor Innovations Group
Hepatology | December 3, 2021 | Volume: 75 | Issue: 6 | Pages: 1579-1589
Abstract Interest in anonymous nondirected living organ donation is increasing in the United States and a small number of transplantation centers are accumulating an experience regarding nondirected donation in living donor liver transplantation. Herein, we review current transplant policy, discuss emerging data, draw parallels from nondirected kidney donation, and examine relevant considerations in nondirected living liver donation. We aim to provide a consensus guidance to ensure safe evaluation and selection of nondirected living liver donors and a schema for just allocation of nondirected grafts.